T-CELL RECEPTOR-MEDIATED STIMULATION OF MOUSE THYMOCYTES INDUCES UP-REGULATION OF THE GM2/GD2 SYNTHASE GENE

被引:20
作者
TAKAMIYA, K
YAMAMOTO, A
YAMASHIRO, S
FURUKAWA, K
HARAGUCHI, M
OKADA, M
IKEDA, T
SHIKU, H
FURUKAWA, K
机构
[1] NAGASAKI UNIV,SCH MED,DEPT ONCOL,NAGASAKI 852,JAPAN
[2] NAGASAKI UNIV,SCH MED,DEPT PATHOL 1,NAGASAKI 852,JAPAN
[3] NAGASAKI UNIV,SCH DENT,DEPT PROSTHODONT,NAGASAKI 852,JAPAN
关键词
GANGLIOSIDE; GLYCOSYLTRANSFERASE; THYMOCYTE; N-ACETYLGALACTOSAMINE; T CELL RECEPTOR;
D O I
10.1016/0014-5793(94)01395-H
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
cDNA clones of the mouse GM2/GD2 synthase (EC 2.4.1.92) gene were isolated, and their analyses revealed that the protein has a type II transmembrane structure with 533 amino acids, which was very similar to the human homolog except for the mRNA size. The mRNA level in thymocytes dramatically increased after treatment with anti-CD3 monoclonal antibody, whereas it was not elevated when treated with prostaglandin E2. In situ hybridization showed an elevation of mRNA levels in medullar thymocytes, suggesting that T cell receptor-mediated signaling induces up-regulation of the GM2/GD2 synthase gene in mature thymocytes.
引用
收藏
页码:79 / 83
页数:5
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