DNA TOPOISOMERASE DYSFUNCTION - A NEW GOAL FOR ANTITUMOR CHEMOTHERAPY

被引：48

作者：

SMITH, PJ

机构：

[1] MRC Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, CB2 2QH, Hills Road

来源：

BIOESSAYS | 1990年 / 12卷 / 04期

关键词：

D O I：

10.1002/bies.950120405

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Topoisomerase enzymes – found in prokaryotes to human cells – control conformational changes in DNA and aid the orderly progression of DNA replication, gene transcription and the separation of daughter chromosomes at cell division. Several classes of anti‐cancer drugs are now recognised as topoisomerase poisons because of their ability to trap topoisomerase molecules on DNA as ‘cleavable complexes’. Understanding how drugs generate such complexes and why they are toxic to actively growing cancer cells is a major challenge for the development of modern approaches to chemotherapy. Copyright © 1990 Cambridge University Press

引用

页码：167 / 172

页数：6

共 45 条

[1] THE PRODUCTION OF CHROMOSOMAL ALTERATIONS IN HUMAN-LYMPHOCYTES BY DRUGS KNOWN TO INTERFERE WITH THE ACTIVITY OF DNA TOPOISOMERASE-II .1. M-AMSA [J].