DNA TOPOISOMERASE DYSFUNCTION - A NEW GOAL FOR ANTITUMOR CHEMOTHERAPY

被引：48

作者：

SMITH, PJ

机构：

[1] MRC Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, CB2 2QH, Hills Road

来源：

BIOESSAYS | 1990年 / 12卷 / 04期

关键词：

D O I：

10.1002/bies.950120405

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Topoisomerase enzymes – found in prokaryotes to human cells – control conformational changes in DNA and aid the orderly progression of DNA replication, gene transcription and the separation of daughter chromosomes at cell division. Several classes of anti‐cancer drugs are now recognised as topoisomerase poisons because of their ability to trap topoisomerase molecules on DNA as ‘cleavable complexes’. Understanding how drugs generate such complexes and why they are toxic to actively growing cancer cells is a major challenge for the development of modern approaches to chemotherapy. Copyright © 1990 Cambridge University Press

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页码：167 / 172

页数：6

相关论文

共 45 条

[11] DNA TOPOISOMERASE .2. A PRIMER ON THE ENZYME AND ITS UNIQUE ROLE AS A MULTIDRUG TARGET IN CANCER-CHEMOTHERAPY [J].

GLISSON, BS ;

ROSS, WE .

PHARMACOLOGY & THERAPEUTICS, 1987, 32 (02) :89-106

[12]

GUPTA RS, 1988, CANCER RES, V48, P6404

[13] DIFFERENTIAL EXPRESSION OF DNA TOPOISOMERASES-I AND TOPOISOMERASES-II DURING THE EUKARYOTIC CELL-CYCLE [J].

HECK, MMS ;

HITTELMAN, WN ;

EARNSHAW, WC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (04) :1086-1090

[14] MODIFICATION OF THE HYDROXY LACTONE RING OF CAMPTOTHECIN - INHIBITION OF MAMMALIAN TOPOISOMERASE-I AND BIOLOGICAL-ACTIVITY [J].

HERTZBERG, RP ;

CARANFA, MJ ;

HOLDEN, KG ;

JAKAS, DR ;

GALLAGHER, G ;

MATTERN, MR ;

MONG, SM ;

BARTUS, JO ;

JOHNSON, RK ;

KINGSBURY, WD .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (03) :715-720

[15] DNA TOPOISOMERASE-II MUST ACT AT MITOSIS TO PREVENT NONDISJUNCTION AND CHROMOSOME BREAKAGE [J].

HOLM, C ;

STEARNS, T ;

BOTSTEIN, D .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (01) :159-168

[16]

HSIANG YH, 1988, CANCER RES, V48, P3230

[17]

KJELDSEN E, 1988, J BIOL CHEM, V263, P3912

[18] ADP-RIBOSYLATION OF ADPR-TRANSFERASE AND TOPOISOMERASE-I IN INTACT MOUSE EPIDERMAL-CELLS JB6 [J].

KRUPITZA, G ;

CERUTTI, P .

BIOCHEMISTRY, 1989, 28 (05) :2034-2040

[19] THE LEUCINE ZIPPER - A HYPOTHETICAL STRUCTURE COMMON TO A NEW CLASS OF DNA-BINDING PROTEINS [J].

LANDSCHULZ, WH ;

JOHNSON, PF ;

MCKNIGHT, SL .

SCIENCE, 1988, 240 (4860) :1759-1764

[20] DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS [J].

LIU, LF .

ANNUAL REVIEW OF BIOCHEMISTRY, 1989, 58 :351-375

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