INFLUENCE OF AGE ON THE PHARMACOKINETICS OF ALFENTANIL - GENDER DEPENDENCE

被引：55

作者：

LEMMENS, HJM

BURM, AGL

HENNIS, PJ

GLADINES, MPPR

BOVILL, JG

机构：

[1] Department of Anesthesiology, University Hospital Leiden, Leiden, 2300 RC

来源：

CLINICAL PHARMACOKINETICS | 1990年 / 19卷 / 05期

关键词：

D O I：

10.2165/00003088-199019050-00005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Studies on the effects of age on the pharmacokinetics of alfentanil are inconclusive. A possible factor in explaining the differences between various studies could be the effect of gender. The authors studied the effects of age on the pharmacokinetics of alfentanil in female (n = 21) and male (n = 15) patients undergoing lower abdominal surgery under nitrous oxide alfentanil anaesthesia. There was a significant negative correlation (r = −0.79, p < 0.001) between plasma alfentanil clearance (CL) and age in women (<50y, median CL 24.84 L/h; >50y, median CL 14.52 L/h), but not in men (<50y, median CL 19.44 L/h; >50y, median CL 16.2 L/h). The conclusion is drawn that the effects of age on the pharmacokinetics of alfentanil are gender-dependent. © 1990, Adis International Limited. All rights reserved.

引用

页码：416 / 422

页数：7