DISCORDANT XENOGRAFT REJECTION IN AN ANTIBODY-FREE MODEL

被引：55

作者：

JOHNSTON, PS ^{[1
]}

WANG, MW ^{[1
]}

LIM, SML ^{[1
]}

WRIGHT, LJ ^{[1
]}

WHITE, DJG ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,ADDENBROOKES HOSP,DEPT SURG,HILLS RD,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

TRANSPLANTATION | 1992年 / 54卷 / 04期

关键词：

D O I：

10.1097/00007890-199210000-00001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Newborn pigs prevented from suckling colostrum were shown to have less than 0.05 mug/ml total immunoglobulin present in their serum. Rabbit heart xenografts transplanted heterotopically into the neck of such pigs were hyperacutely rejected, with a mean survival time of 92+/-14 min (mean+/-SD). Pigs which had been allowed to suckle and whose serum contained 10-15 mg/ml maternal immunoglobulin hyperacutely rejected rabbit heart xenografts in 109+/-62 min. Histological studies showed no Ig binding but complement component 3 (C3) binding to rabbit hearts placed in immunoglobulin-negative pigs. Prolongation of rabbit heart xenograft survival was achieved by administering cobra venom factor (1 mg/kg) to the pigs pretransplant. These data show hyperacute xenograft rejection in the absence of antibody and suggest that its cause is activation of complement by the alternative pathway.

引用

页码：573 / 576

页数：4

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