A NEW CALCITONIN-RECEPTOR-LIKE SEQUENCE IN RAT PULMONARY BLOOD-VESSELS

被引：126

作者：

NJUKI, F

NICHOLL, CG

HOWARD, A

MAK, JCW

BARNES, PJ

GIRGIS, SI

LEGON, S

机构：

[1] HAMMERSMITH HOSP, ROYAL POSTGRAD MED SCH, DEPT CHEM PATHOL, DU CANE RD, LONDON W12 0NN, ENGLAND

[2] HAMMERSMITH HOSP, ROYAL POSTGRAD MED SCH, DEPT MED, LONDON W12 0HS, ENGLAND

[3] NATL HEART & LUNG INST, DEPT THORAC MED, LONDON, ENGLAND

来源：

CLINICAL SCIENCE | 1993年 / 85卷 / 04期

关键词：

AMYLIN; CALCITONIN; CALCITONIN-GENE-RELATED PEPTIDE; HYPOTHALAMUS; ISLET AMYLOID POLYPEPTIDE; LUNG; RECEPTOR;

D O I：

10.1042/cs0850385

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

1. Two rat clones have been isolated which are similar to known calcitonin-receptor sequences. One of these does not have the distribution expected of a calcitonin receptor. It is widely distributed, with extremely high levels of expression in the lung, where it is associated with the blood vessels. 2. This rat sequence may represent the receptor for calcitonin-gene-related peptide or islet amyloid polypeptide. Both have binding activity in the lung and are potent vasodilators. The gene represented by this sequence may therefore play an important role in the maintenance of vascular tone.

引用

页码：385 / 388

页数：4

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