EFFECTS OF CGRP IN DIFFERENT MODELS OF MOUSE EAR INFLAMMATION

被引：26

作者：

CLEMENTI, G

AMICOROXAS, M

CARUSO, A

CUTULI, VMC

PRATO, A

MAUGERI, S

DEBERNARDIS, E

SCAPAGNINI, U

机构：

[1] Institute of Pharmacology, University of Catania School of Medicine

来源：

LIFE SCIENCES | 1994年 / 54卷 / 08期

关键词：

D O I：

10.1016/0024-3205(94)90011-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The anti-inflammatory activity of calcitonin gene-related peptide (CGRP) has been studied in cutaneous inflammation induced by croton oil (CO), arachidonic acid (AA), tetradecanoylphorbol acetate (TPA) or cantharidin (CA). Our results show that mouse ear inflammation induced by CO, AA or TPA is decreased by topical administration of CGRP, whereas that induced by CA is not affected. The dose-response and temporal analysis of CGRP effect show that the maximal activity is present at the dose of 30 pmol/ear and when administered 30 min after the irritating agent. Moreover, pretreatment with capsaicin is able to mimic the anti-inflammatory effect of exogenous CORP, while simultaneous administration of CGRP and capsaicin produces a reduced response. Our results suggest that CGRP released from sensory

引用

页码：PL119 / PL124

页数：6