DETERMINATION OF CHLORAL HYDRATE AND ITS METABOLITES (TRICHLOROETHANOL AND TRICHLORACETIC ACID) IN HUMAN PLASMA AND URINE USING ELECTRON-CAPTURE GAS-CHROMATOGRAPHY

被引:21
作者
HUMBERT, L
JACQUEMONT, MC
LEROY, E
LECLERC, F
HOUDRET, N
LHERMITTE, M
机构
[1] FAC SCI PHARMACEUT & BIOL LILLE,TOXICOL LAB,F-59045 LILLE,FRANCE
[2] HOP CALMETTE,SERV REANIMAT INFANTILE,F-59045 LILLE,FRANCE
关键词
D O I
10.1002/bmc.1130080604
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Capillary gas chromatography with electron capture detection is described for the quantification of chloral hydrate (CH) and is metabolites trichloroethanol (TCE) and trichloroacetic acid (TCA) in 0.1-1 mL of plasma samples. The method, with 2,2'-dichloroethanol (DCE) as internal standard, involved extraction of chloral hydrate and trichloroethanol with diethyl ether and methylation of trichloroacetic acid with 3-methyl-1-tolyltriazene (MTT), followed by diethyl ether extraction. The method has a detection limit of 5 ng/mL for CH and TCE and 10 ng/mL for TCA and also allows the determination of TCE-glucuronide in 0.1-1 mL of plasma samples. It exhibits good linearity and precision. The method was applied to samples of plasma from a neonate after a single dose of 40 mg/kg of chloral hydrate and from an adult after a single dose of 6.25 mg/kg.
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收藏
页码:273 / 277
页数:5
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