EFFECT OF CRYSTAL FORM CORTISONE ALCOHOL AND AGITATION ON CRYSTAL GROWTH OF CORTISONE ACETATE IN AQUEOUS SUSPENSIONS

Particle size distribution in aqueous suspensions of stable and unstable crystal forms of cortisone acetate under conditions of agitation and different degrees of saturation with cortisone alcohol is described. Agitation accelerated the diffusion‐controlled processes of dissolution and crystallization, leading to the formation of a high proportion of large particles. Cortisone alcohol inhibited the polymorphic transformation necessary for the crystal growth and formation of the water‐stable form. The mechanism of action is discussed. 1968 Royal Pharmaceutical Society of Great Britain