FAMILIAL MEDITERRANEAN FEVER - ANALYSIS OF INHERITANCE AND CURRENT LINKAGE DATA

被引：24

作者：

SHOHAT, M

DANON, YL

ROTTER, JI

机构：

[1] BEILINSON MED CTR, CHILDRENS HOSP, DEPT PEDIAT, IL-49100 PETAH TIQWA, ISRAEL

[2] BEILINSON MED CTR, CHILDRENS HOSP, DEPT PEDIAT IMMUNOL, IL-49100 PETAH TIQWA, ISRAEL

[3] FELSENSTEIN MED RES INST, PETAH TIQWA, ISRAEL

[4] TEL AVIV UNIV, SACKLER SCH MED, TEL AVIV, ISRAEL

[5] CEDARS SINAI MED CTR, CTR MED GENET BIRTH DEFECTS, DEPT MED, LOS ANGELES, CA 90048 USA

[6] CEDARS SINAI MED CTR, CTR MED GENET & BIRTH DEFECTS, DEPT PEDIAT, LOS ANGELES, CA 90048 USA

[7] UNIV CALIF LOS ANGELES, SCH MED, LOS ANGELES, CA 90024 USA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1992年 / 44卷 / 02期

关键词：

GENETICS; RECURRENT POLYSEROSITIS; GENE FREQUENCY; LINKAGE STUDIES;

D O I：

10.1002/ajmg.1320440213

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Familial Mediterranean fever (FMF) is a genetic disorder characterized by recurrent attacks of fever and inflammation of serosal surfaces. Unlike many mendelian disorders, the mode of transmission has been subject to some controversy as segregation analysis studies have always demonstrated fewer "observed" than "expected" affected individuals. Despite efforts to map the gene causing FMF, no definite linkage has been yet identified. This review analyses the epidemiologic and genetic characteristics in order to evaluate critically the inheritance of the disease and provide a perspective on the current biochemical and molecular genetic studies whose aim is to locate the gene for this disease.

引用

页码：183 / 188

页数：6

共 44 条

[11] COHEN AS, 1983, LAB INVEST, V48, P1
[12] ELIAKIM M, 1981, RECURRENT POLYSEROSI
[13] EMERY AEH, 1986, METHODOLOGY MED GENE
[14] FRADKIN A, 1985, ISRAEL J MED SCI, V21, P757
[15] GRUBERG L, 1991, HUMAN GENE MAPPING, P274
[16] FAMILIAL MEDITERRANEAN FEVER
HELLER, H
SOHAR, E
SHERF, L
[J]. ARCHIVES OF INTERNAL MEDICINE, 1958, 102 (01) : 50 - 71
[17] Janeway TC, 1908, T ASSOC AM PHYSICIAN, V23, P504
[18] KHACHADURIAN A K, 1974, Birth Defects Original Article Series, V10, P62
[19] LALOUEL JM, 1976, ACTA ANTHROPOGENET, V1, P15
[20] LUSIS AJ, 1988, J LIPID RES, V29, P397

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