LOCOMOTOR INHIBITION BY THE D-3 LIGAND R-(+)-7-OH-DPAT IS INDEPENDENT OF CHANGES IN DOPAMINE RELEASE

被引：141

作者：

SVENSSON, K

CARLSSON, A

WATERS, N

机构：

[1] Department of Pharmacology, University of Göteborg, Göteborg

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1994年 / 95卷 / 01期

关键词：

D-3; RECEPTOR; LOCOMOTOR ACTIVITY; DOPAMINE RELEASE;

D O I：

10.1007/BF01283032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The dopamine D-3 preferring ligand R-(+)-7-OH-DPAT induced strong hypolocomotion in rats. Doses producing reduction of locomotion failed to affect dopamine release or synthesis rate. These data support the hypothesis that the dopamine D-3 receptor is a postsynaptic receptor with an inhibitory influence on rat locomotor activity.

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收藏

页码：71 / 74

页数：4

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