A HIGHLY CONVERGENT STRATEGY TOWARDS RAPAMYCIN - STEREOSELECTIVE CONSTRUCTION OF THE C-8-C-18 FRAGMENT

被引：34

作者：

PISCOPIO, AD

MINOWA, N

CHAKRABORTY, TK

KOIDE, K

BERTINATO, P

NICOLAOU, KC

机构：

[1] UNIV CALIF SAN DIEGO, DEPT CHEM, 9500 GILMAN DR, LA JOLLA, CA 92093 USA

[2] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 07期

关键词：

D O I：

10.1039/c39930000617

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strategy for a total synthesis of the immunosuppressant agent rapamycin 1 is outlined and the stereoselective construction of a suitably functionalized C-8-C18 fragment 2 is described.

引用

页码：617 / 618

页数：2

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