QUANTITATIVE LIQUID-CHROMATOGRAPHY, THERMOSPRAY TANDEM MASS-SPECTROMETRIC (LC/TSP/MS/MS) ANALYSIS OF SOME TRANQUILIZERS OF THE THIOXANTHENE GROUP IN WHOLE-BLOOD

被引：9

作者：

VERWEIJ, AMA ^{[1
]}

HORDIJK, ML ^{[1
]}

LIPMAN, PJL ^{[1
]}

机构：

[1] MINIST JUSTICE,DEPT TOXICOL,FORENS SCI LAB,2288 GD RIJSWIJK,NETHERLANDS

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1994年 / 17卷 / 19期

关键词：

D O I：

10.1080/10826079408013603

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A LC/TSP/MS/MS selected reaction monitoring (SRM) method in the daughter ion scan mode can be succesfully applied for the quantitative determination of members of the Thioxanthenegroup like Chlorprothixene,Flupenthixol,Thiothixene and Zuclopenthixol in whole-blood following a BondElut extraction. Detection limits as low as 100pg for Chlorprothixene varying to 2ng per injection for the other compounds were found (corresponding to 0.5 to 10ng per mL whole-blood). Sensitivity of the proposed method is of the same order of chromatographic methods with other detectors or a RIA method.

引用

页码：4099 / 4110

页数：12

共 8 条

[1]

HEEREMANS CEM, 1990, THESIS U LEIDEN

[2]

MOFFAT AC, 1986, CLARKES ISOLATION ID, P462

[3]

NIESSEN WMA, 1992, LIQUID CHROMATOGRAPH, P157

[4] LIQUID-CHROMATOGRAPHIC, THERMOSPRAY NEGATIVE-ION, TANDEM MASS SPECTROMETRIC(LC TSP MS MS) ANALYSIS OF SOME EXPLOSIVES [J].

VERWEIJ, AMA ;

DEBRUYN, PCAM ;

CHOUFOER, C ;

LIPMAN, PJL .

FORENSIC SCIENCE INTERNATIONAL, 1993, 60 (1-2) :7-13

[5] COMPARISON OF MASS-SPECTROMETRIC TECHNIQUES FOR THE ANALYSIS OF TRACE AMOUNTS OF 1-METHYLAMINOANTHRAQUINONE, USED AS SMOKE DYE IN EXPLODING MONEY SUITCASES [J].

VERWEIJ, AMA ;

LIPMAN, PJL .

JOURNAL OF CHROMATOGRAPHY A, 1993, 653 (02) :359-362

[6] QUANTITATIVE LIQUID-CHROMATOGRAPHY, THERMOSPRAY TANDEM MASS-SPECTROMETRY (LC TSP MS MS) ANALYSIS OF SOME THERMOLABILE BENZODIAZEPINES IN WHOLE-BLOOD [J].

VERWEIJ, AMA ;

LIPMAN, PJL ;

ZWEIPFENNING, PGM .

FORENSIC SCIENCE INTERNATIONAL, 1992, 54 (01) :67-74

[7]

VERWEIJ AMA, IN PRESS J ANAL TOX

[8]

Yinon J, 1991, FORENSIC SCI PROG, V5, P1

← 1 →