SEROTONIN DEPLETION DECREASES THE THERAPEUTIC EFFECT OF NICOTINE, BUT NOT THA, IN MEDIAL SEPTAL-LESIONED RATS

被引：18

作者：

RIEKKINEN, P

SIRVIO, J

RIEKKINEN, M

机构：

[1] Department of Neurology, Canthia building, University of Kuopio, Kuopio, FIN-70211

来源：

BRAIN RESEARCH | 1994年 / 662卷 / 1-2期

关键词：

MEDIAL SEPTUM; SEROTONIN; PA AND SPATIAL NAVIGATION; NICOTINE; THA;

D O I：

10.1016/0006-8993(94)90800-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study compares the effects of systemic pretraining trial injections of a cholinesterase inhibitor, tetrahydroaminoacridine (THA, 1, 3 and 5 mg/kg, i.p.) and nicotine (0.03, 0.1 and 0.3 mg/kg, i.p.) on spatial navigation water maze (WM) and passive avoidance (step-through PA) performance in medial septal (MS) - or MS + p-chlorophenylalanine (PCPA, a serotonin synthesis inhibitor)-lesioned rats. MS-lesion impaired WM and PA acquisition, and serotonin depletion significantly aggravated PA failure of MS-lesioned rats. THA (3 mg/kg) and nicotine (0.1 and 0.3 mg/kg) promoted PA and WM navigation of MS-lesioned rats. THA at a dose of 3 mg/kg improved performance of MS + PCPA-lesioned rats in WM and PA tests, but nicotine did not promote test performance of combined-lesioned rats. This result demonstrates that serotoninergic pathology may decrease the therapeutic effect of nicotine.

引用

页码：95 / 102

页数：8

共 38 条

[21] PHARMACOLOGICAL CONSEQUENCES OF NICOTINERGIC PLUS SEROTONERGIC MANIPULATIONS [J].