ACQUIRED GROWTH-HORMONE RESISTANCE

被引：67

作者：

ROSS, RJM ^{[1
]}

CHEW, SL ^{[1
]}

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT ENDOCRINOL,LONDON,ENGLAND

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 1995年 / 132卷 / 06期

关键词：

D O I：

10.1530/eje.0.1320655

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Growth hormone (GH) resistance is defined biochemically by the finding of high GH and low IGF-I levels, It may be primary, as in Laron's syndrome (GH receptor mutations). Acquired resistance is found in conditions that have in common malnutrition and net protein catabolism. There is evidence to suggest that GH resistance is permissive to protein catabolism and that its reversal may improve the nutritional state of some patients, In this review we discuss the clinical problem, its molecular basis and the possibility of therapeutic intervention with GH and/or IGF-I.

引用

收藏

页码：655 / 660

页数：6

相关论文

共 69 条

[1] REGULATION OF START SITE USAGE IN THE LEADER EXONS OF THE RAT INSULIN-LIKE GROWTH FACTOR-I GENE BY DEVELOPMENT, FASTING, AND DIABETES [J].

ADAMO, ML ;

BENHUR, H ;

ROBERTS, CT ;

LEROITH, D .

MOLECULAR ENDOCRINOLOGY, 1991, 5 (11) :1677-1686

[2] IDENTIFICATION OF JAK2 AS A GROWTH-HORMONE RECEPTOR-ASSOCIATED TYROSINE KINASE [J].

ARGETSINGER, LS ;

CAMPBELL, GS ;

YANG, XN ;

WITTHUHN, BA ;

SILVENNOINEN, O ;

IHLE, JN ;

CARTERSU, C .

CELL, 1993, 74 (02) :237-244

[3] GROWTH-HORMONE SYNERGIZES WITH SERUM GROWTH-FACTORS IN INDUCING C-FOS TRANSCRIPTION IN 3T3-F442A CELLS [J].

ASHCOM, G ;

GURLAND, G ;

SCHWARTZ, J .

ENDOCRINOLOGY, 1992, 131 (04) :1915-1921

[4] REGULATION OF C-FOS PROTOONCOGENE EXPRESSION BY GROWTH-HORMONE - PROTEIN-SYNTHESIS IS NOT REQUIRED FOR DOWN-REGULATION [J].

BARCELLINICOUGET, S ;

DOGLIO, A ;

DANI, C .

ENDOCRINOLOGY, 1993, 132 (04) :1875-1877

[5] INFLUENCE OF NUTRITION AND BOVINE GROWTH-HORMONE (GH) ON HEPATIC GH BINDING, INSULIN-LIKE GROWTH FACTOR-I AND GROWTH OF LAMBS [J].

BASS, JJ ;

OLDHAM, JM ;

HODGKINSON, SC ;

FOWKE, PJ ;

SAUERWEIN, H ;

MOLAN, P ;

BREIER, BH ;

GLUCKMAN, PD .

JOURNAL OF ENDOCRINOLOGY, 1991, 128 (02) :181-186

[6] IN-VIVO PROTEOLYSIS OF SERUM INSULIN-LIKE GROWTH-FACTOR (IGF) BINDING PROTEIN-3 RESULTS IN INCREASED AVAILABILITY OF IGF TO TARGET-CELLS [J].

BLAT, C ;

VILLAUDY, J ;

BINOUX, M .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (05) :2286-2290

[7]

CATANESE VM, 1993, ENDOCRINOLOGY, V132, P796

[8] EXPRESSION OF INSULIN-LIKE GROWTH FACTOR-I IN UREMIC RATS - GROWTH-HORMONE RESISTANCE AND NUTRITIONAL INTAKE [J].

CHAN, W ;

VALERIE, KC ;

CHAN, JCM .

KIDNEY INTERNATIONAL, 1993, 43 (04) :790-795

[9] REVERSAL OF DIET-INDUCED CATABOLISM BY INFUSION OF RECOMBINANT INSULIN-LIKE GROWTH FACTOR-I IN HUMANS [J].

CLEMMONS, DR ;

SMITHBANKS, A ;

UNDERWOOD, LE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 75 (01) :234-238

[10]

COTTERILL AM, 1994, IN PRESS CLIN ENDOCR

← 1 2 3 4 5 6 7 →