ACQUIRED GROWTH-HORMONE RESISTANCE

被引：67

作者：

ROSS, RJM ^{[1
]}

CHEW, SL ^{[1
]}

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT ENDOCRINOL,LONDON,ENGLAND

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 1995年 / 132卷 / 06期

关键词：

D O I：

10.1530/eje.0.1320655

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Growth hormone (GH) resistance is defined biochemically by the finding of high GH and low IGF-I levels, It may be primary, as in Laron's syndrome (GH receptor mutations). Acquired resistance is found in conditions that have in common malnutrition and net protein catabolism. There is evidence to suggest that GH resistance is permissive to protein catabolism and that its reversal may improve the nutritional state of some patients, In this review we discuss the clinical problem, its molecular basis and the possibility of therapeutic intervention with GH and/or IGF-I.

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页码：655 / 660

页数：6

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