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A DIACYLGLYCEROL KINASE IS INVOLVED IN THE REGULATION OF INTERLEUKIN-2 SYNTHESIS IN JURKAT-T CELLS
被引:12
作者
:
AUSSEL, C
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED NICE,INSERM,U343,F-06034 NICE,FRANCE
AUSSEL, C
PELASSY, C
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED NICE,INSERM,U343,F-06034 NICE,FRANCE
PELASSY, C
BREITTMAYER, JP
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED NICE,INSERM,U343,F-06034 NICE,FRANCE
BREITTMAYER, JP
机构
:
[1]
FAC MED NICE,INSERM,U343,F-06034 NICE,FRANCE
[2]
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
来源
:
CELLULAR IMMUNOLOGY
|
1992年
/ 139卷
/ 02期
关键词
:
D O I
:
10.1016/0008-8749(92)90075-Z
中图分类号
:
Q2 [细胞生物学];
学科分类号
:
071009 ;
090102 ;
摘要
:
Diacylglycerol (DAG) plays a prominent role in several activation processes because of its ability, in the presence of calcium ions and phosphatidylserine, to activate C kinase. In T lymphocytes, however, DAG, produced in response to activating mAb or lectins, is rapidly metabolized into phosphatidic acid (PA) which may participate in further steps of activation. We thus investigated the involvement of a DAG kinase in several events subsequent to the activation of Jurkat T cells by CD3 mAb or phytohemagglutunin (PHA). We showed that three inhibitors of DAG kinase abbrogated PA production and impaired calcium release from intracellular compartment, restored phosphatidylserine synthesis, and finally blocked IL-2 production in CD3- and PHA-stimulated cells. Postactivation DAG levels were not modified and DAG kinase inhibitors lowered IL-2 secretion even in the presence of phorbol ester that directly activates the C kinase. These results clearly demonstrate that, beside the effect of DAG on C kinase, DAG kinase dependent production of PA is crucial for further steps of T cell activation. © 1992.
引用
收藏
页码:333 / 341
页数:9
相关论文
共 24 条
[11]
DIACYLGLYCEROL KINASE - A KEY MODULATOR OF SIGNAL TRANSDUCTION
KANOH, H
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Biochemistry, Sapporo Medical College West-17, Sapporo, 060
KANOH, H
YAMADA, K
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Biochemistry, Sapporo Medical College West-17, Sapporo, 060
YAMADA, K
SAKANE, F
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Biochemistry, Sapporo Medical College West-17, Sapporo, 060
SAKANE, F
[J].
TRENDS IN BIOCHEMICAL SCIENCES,
1990,
15
(02)
: 47
-
50
[12]
EPIDERMAL GROWTH-FACTOR STIMULATES DIACYLGLYCEROL KINASE IN ISOLATED PLASMA-MEMBRANE VESICLES FROM A431-CELLS
KATO, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
KATO, M
HOMMA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
HOMMA, Y
NAGAI, Y
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
NAGAI, Y
TAKENAWA, T
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
TAKENAWA, T
[J].
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1985,
129
(02)
: 375
-
380
[13]
MARY D, 1988, J IMMUNOL, V141, P3078
[14]
GROWTH FACTOR-LIKE ACTION OF PHOSPHATIDIC-ACID
MOOLENAAR, WH
论文数:
0
引用数:
0
h-index:
0
MOOLENAAR, WH
KRUIJER, W
论文数:
0
引用数:
0
h-index:
0
KRUIJER, W
TILLY, BC
论文数:
0
引用数:
0
h-index:
0
TILLY, BC
VERLAAN, I
论文数:
0
引用数:
0
h-index:
0
VERLAAN, I
BIERMAN, AJ
论文数:
0
引用数:
0
h-index:
0
BIERMAN, AJ
DELAAT, SW
论文数:
0
引用数:
0
h-index:
0
DELAAT, SW
[J].
NATURE,
1986,
323
(6084)
: 171
-
173
[15]
MURAYAMA T, 1987, J BIOL CHEM, V262, P5522
[16]
TRANSMEMBRANE SIGNALING VIA THE T11-DEPENDENT PATHWAY OF HUMAN T-CELL ACTIVATION - EVIDENCE FOR THE INVOLVEMENT OF 1,2-DIACYLGLYCEROL AND INOSITOL PHOSPHATES
PANTALEO, G
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
PANTALEO, G
OLIVE, D
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
OLIVE, D
POGGI, A
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
POGGI, A
KOZUMBO, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
KOZUMBO, WJ
MORETTA, L
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
MORETTA, L
MORETTA, A
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
MORETTA, A
[J].
EUROPEAN JOURNAL OF IMMUNOLOGY,
1987,
17
(01)
: 55
-
60
[17]
INHIBITION OF PHOSPHATIDYLSERINE SYNTHESIS INDUCED BY TRIGGERING CD2 OR THE CD3-TCR COMPLEX IN A HUMAN T-CELL LINE - RELATIONSHIPS WITH G-PROTEINS AND RECEPTORS MODULATION
PELASSY, C
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
PELASSY, C
DALLANEGRA, A
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
DALLANEGRA, A
AUSSEL, C
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
AUSSEL, C
FEHLMANN, M
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
FEHLMANN, M
[J].
MOLECULAR IMMUNOLOGY,
1989,
26
(11)
: 1081
-
1086
[18]
PHOSPHOLIPID-METABOLISM AND T-CELL ACTIVATION - RECEPTOR TRIGGERING IS ASSOCIATED WITH THE INHIBITION OF PHOSPHATIDYLSERINE SYNTHESIS
PELASSY, C
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
PELASSY, C
AUSSEL, C
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
AUSSEL, C
FEHLMANN, M
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
FEHLMANN, M
[J].
CELLULAR SIGNALLING,
1989,
1
(01)
: 99
-
105
[19]
PELASSY C, 1991, IN PRESS CELL SIGNAL
[20]
DIFFERENT EFFECTS OF SPHINGOSINE, R59022 AND ANIONIC AMPHIPHILES ON 2 DIACYLGLYCEROL KINASE ISOZYMES PURIFIED FROM PORCINE THYMUS CYTOSOL
SAKANE, F
论文数:
0
引用数:
0
h-index:
0
机构:
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
SAKANE, F
YAMADA, K
论文数:
0
引用数:
0
h-index:
0
机构:
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
YAMADA, K
KANOH, H
论文数:
0
引用数:
0
h-index:
0
机构:
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
KANOH, H
[J].
FEBS LETTERS,
1989,
255
(02)
: 409
-
413
←
1
2
3
→
共 24 条
[11]
DIACYLGLYCEROL KINASE - A KEY MODULATOR OF SIGNAL TRANSDUCTION
KANOH, H
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Biochemistry, Sapporo Medical College West-17, Sapporo, 060
KANOH, H
YAMADA, K
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Biochemistry, Sapporo Medical College West-17, Sapporo, 060
YAMADA, K
SAKANE, F
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Biochemistry, Sapporo Medical College West-17, Sapporo, 060
SAKANE, F
[J].
TRENDS IN BIOCHEMICAL SCIENCES,
1990,
15
(02)
: 47
-
50
[12]
EPIDERMAL GROWTH-FACTOR STIMULATES DIACYLGLYCEROL KINASE IN ISOLATED PLASMA-MEMBRANE VESICLES FROM A431-CELLS
KATO, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
KATO, M
HOMMA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
HOMMA, Y
NAGAI, Y
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
NAGAI, Y
TAKENAWA, T
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,7-3-1 HONGO,TOKYO 113,JAPAN
TAKENAWA, T
[J].
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1985,
129
(02)
: 375
-
380
[13]
MARY D, 1988, J IMMUNOL, V141, P3078
[14]
GROWTH FACTOR-LIKE ACTION OF PHOSPHATIDIC-ACID
MOOLENAAR, WH
论文数:
0
引用数:
0
h-index:
0
MOOLENAAR, WH
KRUIJER, W
论文数:
0
引用数:
0
h-index:
0
KRUIJER, W
TILLY, BC
论文数:
0
引用数:
0
h-index:
0
TILLY, BC
VERLAAN, I
论文数:
0
引用数:
0
h-index:
0
VERLAAN, I
BIERMAN, AJ
论文数:
0
引用数:
0
h-index:
0
BIERMAN, AJ
DELAAT, SW
论文数:
0
引用数:
0
h-index:
0
DELAAT, SW
[J].
NATURE,
1986,
323
(6084)
: 171
-
173
[15]
MURAYAMA T, 1987, J BIOL CHEM, V262, P5522
[16]
TRANSMEMBRANE SIGNALING VIA THE T11-DEPENDENT PATHWAY OF HUMAN T-CELL ACTIVATION - EVIDENCE FOR THE INVOLVEMENT OF 1,2-DIACYLGLYCEROL AND INOSITOL PHOSPHATES
PANTALEO, G
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
PANTALEO, G
OLIVE, D
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
OLIVE, D
POGGI, A
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
POGGI, A
KOZUMBO, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
KOZUMBO, WJ
MORETTA, L
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
MORETTA, L
MORETTA, A
论文数:
0
引用数:
0
h-index:
0
机构:
IST NAZL RIC CANC,GENOVA,ITALY
MORETTA, A
[J].
EUROPEAN JOURNAL OF IMMUNOLOGY,
1987,
17
(01)
: 55
-
60
[17]
INHIBITION OF PHOSPHATIDYLSERINE SYNTHESIS INDUCED BY TRIGGERING CD2 OR THE CD3-TCR COMPLEX IN A HUMAN T-CELL LINE - RELATIONSHIPS WITH G-PROTEINS AND RECEPTORS MODULATION
PELASSY, C
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
PELASSY, C
DALLANEGRA, A
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
DALLANEGRA, A
AUSSEL, C
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
AUSSEL, C
FEHLMANN, M
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
FAC MED PASTEUR,INSERM,U210,UNITE RECH IMMUNOL CELLULAIRE & MOLEC,F-06034 NICE,FRANCE
FEHLMANN, M
[J].
MOLECULAR IMMUNOLOGY,
1989,
26
(11)
: 1081
-
1086
[18]
PHOSPHOLIPID-METABOLISM AND T-CELL ACTIVATION - RECEPTOR TRIGGERING IS ASSOCIATED WITH THE INHIBITION OF PHOSPHATIDYLSERINE SYNTHESIS
PELASSY, C
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
PELASSY, C
AUSSEL, C
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
AUSSEL, C
FEHLMANN, M
论文数:
0
引用数:
0
h-index:
0
机构:
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
FAC MED NICE,INSERM,U210,F-06034 NICE,FRANCE
FEHLMANN, M
[J].
CELLULAR SIGNALLING,
1989,
1
(01)
: 99
-
105
[19]
PELASSY C, 1991, IN PRESS CELL SIGNAL
[20]
DIFFERENT EFFECTS OF SPHINGOSINE, R59022 AND ANIONIC AMPHIPHILES ON 2 DIACYLGLYCEROL KINASE ISOZYMES PURIFIED FROM PORCINE THYMUS CYTOSOL
SAKANE, F
论文数:
0
引用数:
0
h-index:
0
机构:
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
SAKANE, F
YAMADA, K
论文数:
0
引用数:
0
h-index:
0
机构:
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
YAMADA, K
KANOH, H
论文数:
0
引用数:
0
h-index:
0
机构:
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
SAPPORO MED COLL,DEPT BIOCHEM,W 17 S 1,SAPPORO,HOKKAIDO 060,JAPAN
KANOH, H
[J].
FEBS LETTERS,
1989,
255
(02)
: 409
-
413
←
1
2
3
→