学术探索
学术期刊
新闻热点
数据分析
智能评审

A REMARKABLE CHANGE OF OPIOID RECEPTOR SELECTIVITY ON THE ATTACHMENT OF A PEPTIDOMIMETIC KAPPA ADDRESS ELEMENT TO THE DELTA ANTAGONIST, NATRINDOLE - 5'-[(N-2-ALKYLAMIDINO)METHYL]NALTRINDOLE DERIVATIVES AS A NOVEL CLASS OF KAPPA OPIOID RECEPTOR ANTAGONISTS

被引：36
作者：
OLMSTED, SL
TAKEMORI, AE
PORTOGHESE, PS
机构：
[1] UNIV MINNESOTA,COLL PHARM,DEPT MED CHEM,MINNEAPOLIS,MN 55455
[2] UNIV MINNESOTA,SCH MED,DEPT PHARMACOL,MINNEAPOLIS,MN 55455
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 36卷 / 01期
关键词：
D O I：
10.1021/jm00053a025
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：179 / 180
页数：2
相关论文
共 17 条
  • [1] SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW ANTIMUSCARINIC COMPOUNDS WITH AMIDINE BASIC CENTERS - A USEFUL BIOISOSTERIC REPLACEMENT OF CLASSICAL CATIONIC HEADS
    CEREDA, E
    EZHAYA, A
    QUINTERO, MG
    BELLORA, E
    DUBINI, E
    MICHELETTI, R
    SCHIAVONE, A
    BRAMBILLA, A
    SCHIAVI, GB
    DONETTI, A
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (08) : 2108 - 2113
  • [2] SPECIFIC RECEPTOR FOR THE OPIOID PEPTIDE DYNORPHIN - STRUCTURE-ACTIVITY-RELATIONSHIPS
    CHAVKIN, C
    GOLDSTEIN, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10): : 6543 - 6547
  • [3] ANALOGS OF BETA-LPH61-64 POSSESSING SELECTIVE AGONIST ACTIVITY AT MU-OPIATE RECEPTORS
    HANDA, BK
    LANE, AC
    LORD, JAH
    MORGAN, BA
    RANCE, MJ
    SMITH, CFC
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1981, 70 (04) : 531 - 540
  • [4] NEW EXAMPLE OF A MORPHINE-SENSITIVE NEURO-EFFECTOR JUNCTION - ADRENERGIC TRANSMISSION IN MOUSE VAS-DEFERENS
    HENDERSON, G
    HUGHES, J
    KOSTERLITZ, HW
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1972, 46 (04) : 764 - 766
  • [5] [H-3]U-69593 A HIGHLY SELECTIVE LIGAND FOR THE OPIOID K-RECEPTOR
    LAHTI, RA
    MICKELSON, MM
    MCCALL, JM
    VONVOIGTLANDER, PF
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 109 (02) : 281 - 284
  • [6] BIS-PENICILLAMINE ENKEPHALINS POSSESS HIGHLY IMPROVED SPECIFICITY TOWARD DELTA-OPIOID RECEPTORS
    MOSBERG, HI
    HURST, R
    HRUBY, VJ
    GEE, K
    YAMAMURA, HI
    GALLIGAN, JJ
    BURKS, TF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (19): : 5871 - 5874
  • [7] BIVALENT LIGANDS AND THE MESSAGE-ADDRESS CONCEPT IN THE DESIGN OF SELECTIVE OPIOID RECEPTOR ANTAGONISTS
    PORTOGHESE, PS
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (06) : 230 - 235
  • [8] STEREOCHEMICAL STUDIES ON MEDICINAL AGENTS .31. ONLY ONE PHARMACOPHORE IS REQUIRED FOR THE K-OPIOID ANTAGONIST SELECTIVITY OF NORBINALTORPHIMINE
    PORTOGHESE, PS
    NAGASE, H
    TAKEMORI, AE
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (07) : 1344 - 1347
  • [9] ROLE OF THE SPACER IN CONFERRING KAPPA-OPIOID RECEPTOR SELECTIVITY TO BIVALENT LIGANDS RELATED TO NORBINALTORPHIMINE
    PORTOGHESE, PS
    GARZONABURBEH, A
    NAGASE, H
    LIN, CE
    TAKEMORI, AE
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (04) : 1292 - 1296
  • [10] DESIGN OF PEPTIDOMIMETIC DELTA-OPIOID RECEPTOR ANTAGONISTS USING THE MESSAGE ADDRESS CONCEPT
    PORTOGHESE, PS
    SULTANA, M
    TAKEMORI, AE
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (06) : 1714 - 1720
12