MUPIROCIN RESISTANCE IN METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS FROM A VETERANS-HOSPITAL

被引：16

作者：

NAGUIB, MH

NAGUIB, MT

FLOURNOY, DJ

机构：

[1] VAMC,MED LAB,921 NE 13TH ST,OKLAHOMA CITY,OK 73104

[2] UNIV OKLAHOMA HLTH SCI CTR,HLTH SCI CTR,DEPT MED,OKLAHOMA CITY,OK 73190

[3] UNIV OKLAHOMA HLTH SCI CTR,HLTH SCI CTR,DEPT PATHOL,OKLAHOMA CITY,OK 73190

[4] VET AFFAIRS MED CTR,MED SERV,OKLAHOMA CITY,OK

来源：

CHEMOTHERAPY | 1993年 / 39卷 / 06期

关键词：

STAPHYLOCOCCUS-AUREUS; METHICILLIN RESISTANCE; MUPIROCIN; MULTIDRUG RESISTANCE; NOSOCOMIAL INFECTIONS; COMMUNITY-ACQUIRED INFECTIONS;

D O I：

10.1159/000238984

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

679 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) which occurred from 1986 and 1992 were retrospectively tested to determine the frequency of mupirocin resistance. With disk agar diffusion screening, 26 of 679 MRSA had zones of inhibition of < 18 mm using a 5 mug mupirocin disk. Minimal inhibitory concentrations (MICs) by agar dilution on the 26 suspect MRSA revealed that 9 were resistant. Of these 9, 1 had a MIC of 6.25, 4 of 12.5, 1 of 25, 1 of 500 and 2 of > 1,000 mug/ml. Although the overall incidence of mupirocin resistance was low in our hospital, 5 of the 9 resistant isolates occurred in 1992 and may signal a much more serious threat in the future.

引用

页码：400 / 404

页数：5

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