ENKEPHALIN-DOPAMINE INTERACTIONS IN THE CENTRAL AMYGDALAR NUCLEUS DURING GASTRIC STRESS-ULCER FORMATION IN RATS

被引：26

作者：

RAY, A ^{[1
]}

HENKE, PG ^{[1
]}

机构：

[1] ST FRANCIS XAVIER UNIV,DEPT PSYCHOL,ANTIGONISH B2G 1C0,NS,CANADA

来源：

BEHAVIOURAL BRAIN RESEARCH | 1990年 / 36卷 / 1-2期

关键词：

Central amygdala; Dopamine; Enkephalin; Stress ulcer;

D O I：

10.1016/0166-4328(90)90172-B

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Intra-amygdalar (i/am) microinjections of the enkephalin analog, (d-Ala2)-Met-enkephalinamide (DAMEA, 3, 10 and 30 μg) into the central amygdalar nucleus (CEA) produced a dose-related, naltrexone-reversible attenuation of cold restraint (3 h at 4°C)-induced gastric mucosal lesions in rats. Similarly, gastric stress ulcer formation was also inhibited by i/am dopamine (DA, 10 μg) - an effect which was reversed by the DA-antagonist, clozapine (5 mg/kg) pretreatment. Further, pretreatment of rats with clozapine or the DA-neurotoxin, 6-hydroxydopamine (6-OHDA, 10 μg, i/am) clearly reversed and/or antagonized the gastric cytoprotective effect of DAMEA (30 μg). The results indicate interactions between enkephalinergic and DAergic systems at the level of the CEA in the maintenance of gastric mucosal integrity during immobilization stress. © 1990.

引用

页码：179 / 183

页数：5

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