LOW CONCENTRATIONS OF N-METHYL-D-ASPARTATE INHIBIT THE INDUCTION OF LONG-TERM POTENTIATION IN RAT HIPPOCAMPAL SLICES

被引：58

作者：

IZUMI, Y

CLIFFORD, DB

ZORUMSKI, CF

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 AUDUBON AVE,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,DEPT NEUROL,ST LOUIS,MO 63110

[3] WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL,ST LOUIS,MO 63110

来源：

NEUROSCIENCE LETTERS | 1992年 / 137卷 / 02期

关键词：

N-METHYL-D-ASPARTATE; GLUTAMATE; ASPARTATE; LONG-TERM POTENTIATION; HIPPOCAMPUS;

D O I：

10.1016/0304-3940(92)90414-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have examined the effects of excitatory amino acids on tetanus-induced long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. Agonists acting at N-methyl-D-aspartate (NMDA) receptors, including NMDA, aspartate and glutamate, completely block the development of LTP when administered for 5 min prior to tetanic stimulation. Additionally, and unlike the NMDA receptor antagonist 2-amino-5-phosphonovalerate (APV), NMDA blocks LTP when administered for 5 min immediately following the electrical tetanus. The effective concentrations of NMDA are subthreshold for depolarizing CA1 neurons. These results indicate that under certain conditions NMDA receptor activation prevents CA1 LTP.

引用

页码：245 / 248

页数：4

共 16 条

[1] ELEVATION OF THE EXTRACELLULAR CONCENTRATIONS OF GLUTAMATE AND ASPARTATE IN RAT HIPPOCAMPUS DURING TRANSIENT CEREBRAL-ISCHEMIA MONITORED BY INTRACEREBRAL MICRODIALYSIS [J].