EFFECT OF ALPHA-GLUCOSIDASE INHIBITION ON THE NONENZYMATIC GLYCATION OF GLOMERULAR-BASEMENT-MEMBRANE

被引：13

作者：

COHEN, MP

KLEPSER, H

WU, VY

机构：

来源：

GENERAL PHARMACOLOGY | 1991年 / 22卷 / 03期

关键词：

D O I：

10.1016/0306-3623(91)90016-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effect of the alpha-glucosidase inhibitor Acarbose on integrated glycemic control and on nonenzymatic glycation of glomerular basement membrane was examined in streptozotocin diabetic rats. 2. Treatment with Acarbose for 8 weeks after induction of diabetes significantly reduced the level of HbA1c and of glomerular basement membrane glycation. 3. Acarbose exerts a significant antihyperglycemic effect and has a salutary influence on the nephropathic process in experimental diabetes.

引用

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页码：515 / 519

页数：5

相关论文

共 38 条

[1] THERMAL-STABILITY OF COLLAGEN IN RELATION TO NON-ENZYMATIC GLYCOSYLATION AND BROWNING INVITRO [J].

ANDREASSEN, TT ;

OXLUND, H .

DIABETOLOGIA, 1985, 28 (09) :687-691

[2]

ANDREASSON TT, 1983, BIOCHIM BIOPHYS ACTA, V677, P313

[3]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[4] COVALENT ATTACHMENT OF SOLUBLE-PROTEINS BY NONENZYMATICALLY GLYCOSYLATED COLLAGEN - ROLE IN THE INSITU FORMATION OF IMMUNE-COMPLEXES [J].

BROWNLEE, M ;

PONGOR, S ;

CERAMI, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (05) :1739-1744

[5] NONENZYMATIC GLYCOSYLATION PRODUCTS ON COLLAGEN COVALENTLY TRAP LOW-DENSITY LIPOPROTEIN [J].

BROWNLEE, M ;

VLASSARA, H ;

CERAMI, A .

DIABETES, 1985, 34 (09) :938-941

[6] MEASUREMENT OF GLYCOSYLATED AMINO-ACIDS AND PEPTIDES FROM URINE OF DIABETIC-PATIENTS USING AFFINITY-CHROMATOGRAPHY [J].

BROWNLEE, M ;

VLASSARA, H ;

CERAMI, A .

DIABETES, 1980, 29 (12) :1044-1047

[7] NONENZYMATIC GLYCOSYLATION AND THE PATHOGENESIS OF DIABETIC COMPLICATIONS [J].

BROWNLEE, M ;

VLASSARA, H ;

CERAMI, A .

ANNALS OF INTERNAL MEDICINE, 1984, 101 (04) :527-537

[8]

BROWNLEE M, 1988, NEW ENGL J MED, V318, P1315

[9] ULTRASTRUCTURAL AND BIOCHEMICAL ANALYSES OF ISOLATED BASEMENT-MEMBRANES FROM KIDNEY GLOMERULI AND TUBULES AND BRAIN AND RETINAL MICROVESSELS [J].

CARLSON, EC ;

BRENDEL, K ;

HJELLE, JT ;

MEEZAN, E .

JOURNAL OF ULTRASTRUCTURE RESEARCH, 1978, 62 (01) :26-53

[10] INCREASED GLYCOSYLATION OF GLOMERULAR BASEMENT-MEMBRANE COLLAGEN IN DIABETES [J].

COHEN, MP ;

URDANIVIA, E ;

SURMA, M ;

WU, VY .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 95 (02) :765-769

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