EFFECT OF ALPHA-GLUCOSIDASE INHIBITION ON THE NONENZYMATIC GLYCATION OF GLOMERULAR-BASEMENT-MEMBRANE

被引：13

作者：

COHEN, MP

KLEPSER, H

WU, VY

机构：

来源：

GENERAL PHARMACOLOGY | 1991年 / 22卷 / 03期

关键词：

D O I：

10.1016/0306-3623(91)90016-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effect of the alpha-glucosidase inhibitor Acarbose on integrated glycemic control and on nonenzymatic glycation of glomerular basement membrane was examined in streptozotocin diabetic rats. 2. Treatment with Acarbose for 8 weeks after induction of diabetes significantly reduced the level of HbA1c and of glomerular basement membrane glycation. 3. Acarbose exerts a significant antihyperglycemic effect and has a salutary influence on the nephropathic process in experimental diabetes.

引用

收藏

页码：515 / 519

页数：5

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