NATURALLY-OCCURRING INHIBITORS OF TOPOISOMERASE-I MEDIATED DNA RELAXATION

被引：49

作者：

BERRY, DE ^{[1
]}

MACKENZIE, L ^{[1
]}

SHULTIS, EA ^{[1
]}

CHAN, JA ^{[1
]}

HECHT, SM ^{[1
]}

机构：

[1] UNIV VIRGINIA, DEPT CHEM & BIOL, CHARLOTTESVILLE, VA 22901 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 02期

关键词：

D O I：

10.1021/jo00028a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay-guided fractionation of a methanol extract of Erodium stephanianum found to inhibit DNA topoisomerase I mediated DNA relaxation afforded corilagin (1) and chebulagic acid (2). The latter is the most potent inhibitor of mammalian topoisomerase I yet reported.

引用

页码：420 / 422

页数：3

共 49 条

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