AMPHETAMINE-LIKE EFFECT OF L-DEPRENYL (SELEGILINE) IN DRUG DISCRIMINATION STUDIES

被引：22

作者：

YASAR, S

BERGMAN, J

机构：

[1] HARVARD UNIV,NEW ENGLAND REG PRIMATE RES CTR,SCH MED,SOUTHBOROUGH,MA 01772

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT ANESTHESIOL & CRIT CARE MED,BALTIMORE,MD

[3] NIDA,PRECLIN PHARMACOL BRANCH,INTRAMURAL RES PROGRAM,BALTIMORE,MD

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 1994年 / 56卷 / 06期

关键词：

D O I：

10.1038/clpt.1994.207

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

l-Deprenyl has dose-dependent amphetamine- and methamphetamine-like discriminative stimulus properties in rats and monkeys. However, these actions occur only at doses that are well above the clinically relevant dose range for l-deprenyl and are likely to reflect its metabolic conversion to amphetamine products. In view of its weak potency for producing amphetamine-like effects and their slow onset, it may not be surprising that l-deprenyl does not appear to have amphetamine-like abuse potential and has been used therapeutically in the treatment of Parkinson syndrome for more than 20 years with no reported instances of abuse.

引用

页码：768 / 773

页数：6

共 31 条

[21] AMPHETAMINE, P-HYDROXYAMPHETAMINE AND BETA-PHENETHYLAMINE IN MOUSE-BRAIN AND URINE AFTER (-)- AND (+)-DEPRENYL ADMINISTRATION [J].