OXIDATION AND ELIMINATION-REACTIONS STUDY IN A FORMAL SYNTHESIS OF (+/-)-FORSKOLIN

被引：11

作者：

ANIES, C ^{[1
]}

PANCRAZI, A ^{[1
]}

LALLEMAND, JY ^{[1
]}

机构：

[1] ECOLE POLYTECH,DCSO,CNRS,ORGAN SYNTH LAB,F-91128 PALAISEAU,FRANCE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 12期

关键词：

FORMAL SYNTHESIS; FORSKOLIN; OXIDATION; ELIMINATION REACTION;

D O I：

10.1016/0040-4039(95)00223-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

From the dihydrofuran derivative 3, an mCPBA oxidation followed by an LAH reduction led to the 9 beta-hydroxy lactol 11, the Jones' oxidation of which gave the 9 beta-hydroxy lactone 13 together with the formyl ketone compound 7. Treatment of 13 with SOCl(2-)Py finally produced the Ziegler-Corey-Ikegami intermediate lactone 2 leading to a formal synthesis of (+/-)-forskoline.

引用

页码：2075 / 2078

页数：4

共 32 条

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