APPLICATION OF WHOLE-BODY AUTORADIOGRAPHY TO A STUDY OF DISTRIBUTION METABOLISM AND MODE OF EXCRETION OF 35S-LABELLED ARYL SULPHATE ESTERS

The technique of whole-body autoradiography has been used to study the distribution, metabolism and mode of excretion of potassium cyclohexylphenyl 4-35S-sulphate, potassium cyclohexylphenyl 2-35S-sulphate, potassium biphenylyl 4-35S-sulphate, potassium naphthyl 2-35S-sulphate and potassium 5,6,7,8-tetrahydro-naphthyl 2-35S-sulphate. The validity of the interpretations of whole-body autoradiograms have been assessed in the light of the results of conventional quantitative and qualitative investigations. The results clearly demonstrate that it is not only possible to obtain information relating to the site and extent of metabolic conversion but in some instances it is also possible to gain insight into the nature of certain metabolic conversions. © 1969.