EFFECT OF ANTICONVULSANT DRUGS ON PERIPHERAL BENZODIAZEPINE RECEPTORS OF HUMAN-LYMPHOCYTES

被引：17

作者：

FERRARESE, C ^{[1
]}

MARZORATI, C ^{[1
]}

PEREGO, M ^{[1
]}

BIANCHI, G ^{[1
]}

CAVARRETTA, R ^{[1
]}

PIERPAOLI, C ^{[1
]}

MORETTI, G ^{[1
]}

FRATTOLA, L ^{[1
]}

机构：

[1] SCI INST EUGENIO MEDEA,BOSISIO PARINI,ITALY

来源：

NEUROPHARMACOLOGY | 1995年 / 34卷 / 04期

关键词：

PERIPHERAL BENZODIAZEPINE RECEPTORS; ANTICONVULSANT DRUGS; LYMPHOCYTES; IMMUNOLOGY;

D O I：

10.1016/0028-3908(95)00001-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Anticonvulsant drugs, such as carbamazepine, may exert some of their effects through peripheral benzodiazepine receptors (PER), which are present in glial cells and regulate the synthesis of neurosteroids. PER have also been demonstrated in human lymphocytes, where they might be used as peripheral markers of anticonvulsant drug effects. In the present paper we investigated the interaction of various antiepileptic drugs with PER of human lymphocytes and evaluated possible effects of acute and chronic treatment with these drugs. At normal therapeutic concentrations, diazepam, carbamazepine and phenobarbital occupy respectively 70, 30 and 10% of PER sites in human lymphocytes. Although no change of receptor density or affinity was observed after acute in vitro treatment, in epileptic patients chronically treated with carbamazepine, phenobarbital and valproic acid, PER B-max was increased with respect to controls and untreated epileptics. Since PER of human lymphocytes may be affected by anticonvulsant drug treatment, we suggest that they might be involved in the immunological alterations reported in these patients and might be used as peripheral markers of drug effects on the central nervous system.

引用

页码：427 / 431

页数：5

共 29 条

[11] PRO-CONVULSANT AND ANTI-CONVULSANT PROPERTIES OF PK-11195, A LIGAND FOR BENZODIAZEPINE BINDING-SITES - DEVELOPMENT OF TOLERANCE [J].