CHROMATOGRAPHIC AND MASS-SPECTROMETRIC METHODS FOR DETERMINATION OF LYSERGIC-ACID DIETHYLAMIDE (LSD) AND METABOLITES IN BODY-FLUIDS

被引:38
作者
NELSON, CC [1 ]
FOLTZ, RL [1 ]
机构
[1] NW TOXICOL INC,SALT LAKE CITY,UT 84124
来源
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 580卷 / 1-2期
关键词
D O I
10.1016/0378-4347(92)80530-4
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Continued illicit use of the potent psychedelic drug lysergic acid diethylamide (LSD) has stimulated efforts to develop effective analytical methods for detection of the drug and its metabolites in body fluids from suspected LSD users. Recently reported methods based on gas and liquid chromatography, combined with single- and multiple-stage mass spectral analysis, now permit accurate detection and quantitation of LSD at sub-nanogram/milliliter concentrations.
引用
收藏
页码:97 / 109
页数:13
相关论文
共 41 条
[21]   QUANTIFICATION OF LSD AND N-DEMETHYL-LSD IN URINE BY GAS-CHROMATOGRAPHY RESONANCE ELECTRON-CAPTURE IONIZATION MASS-SPECTROMETRY [J].
LIM, HK ;
ANDRENYAK, D ;
FRANCOM, P ;
FOLTZ, RL ;
JONES, RT .
ANALYTICAL CHEMISTRY, 1988, 60 (14) :1420-1425
[22]   CONFIRMATION OF LSD INTOXICATION BY ANALYSIS OF SERUM AND URINE [J].
MCCARRON, MM ;
WALBERG, CB ;
BASELT, RC .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1990, 14 (03) :165-167
[23]  
MCDONALD P, 1984, J FORENSIC SCI, V29, P120
[24]  
NELSON CC, 1992, IN PRESS ANAL CHEM
[25]   DIRECT QUANTITATIVE-ANALYSIS OF LYSERGIC-ACID DIETHYLAMIDE (LSD) AND 2,5-DIMETHOXY-4-METHYLAMPHETAMINE (STP) ON THIN-LAYER CHROMATOGRAMS [J].
NIWAGUCHI, T ;
INOUE, T .
JOURNAL OF CHROMATOGRAPHY, 1976, 121 (01) :165-169
[26]   MEASUREMENT OF LYSERGIC-ACID DIETHYLAMIDE (LSD) IN HUMAN PLASMA BY GAS-CHROMATOGRAPHY NEGATIVE-ION CHEMICAL IONIZATION MASS-SPECTROMETRY [J].
PAPAC, DI ;
FOLTZ, RL .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1990, 14 (03) :189-190
[27]   GAS-CHROMATOGRAPHIC ELECTRON-IMPACT MASS FRAGMENTOMETRIC DETERMINATION OF LYSERGIC-ACID DIETHYLAMIDE IN URINE [J].
PAUL, BD ;
MITCHELL, JM ;
BURBAGE, R ;
MOY, M ;
SROKA, R .
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 529 (01) :103-112
[28]  
SELIGMANN J, 1992, NEWSWEEK 0203, P66
[29]   FATE OF LYSERGIC-ACID DIETHYLAMIDE-C-14 ([LSD-C-14) IN THE RAT, GUINEA-PIG AND RHESUS-MONKEY AND OF [ISO-LSD-C-14 IN RAT [J].
SIDDIK, ZH ;
BARNES, RD ;
DRING, LG ;
SMITH, RL ;
WILLIAMS, RT .
BIOCHEMICAL PHARMACOLOGY, 1979, 28 (20) :3093-3101
[30]   BODY-FLUID LEVELS OF LYSERGIDE (LSD) [J].
SMITH, RN ;
ROBINSON, K .
FORENSIC SCIENCE INTERNATIONAL, 1985, 28 (3-4) :229-237