USE OF A BASE-LABILE PROTECTED DERIVATIVE OF 6-MERCAPTOHEXANOL FOR THE PREPARATION OF OLIGONUCLEOTIDES CONTAINING A THIOL-GROUP AT THE 5'-END

被引：11

作者：

DELATORRE, BG ^{[1
]}

AVINO, AM ^{[1
]}

ESCARCELLER, M ^{[1
]}

ROYO, M ^{[1
]}

ALBERICIO, F ^{[1
]}

ERITJA, R ^{[1
]}

机构：

[1] UNIV BARCELONA,DPT ORGAN CHEM,E-08028 BARCELONA,SPAIN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1993年 / 12卷 / 09期

关键词：

D O I：

10.1080/07328319308018569

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The preparation of a base-labile (Dnpe) protected derivative of 6-mercaptohexanol is described. The use of the phosphoramidite derivative of this compound improves both yields and the time needed for the preparation of oligonucleotides containing a thiol group at the 5'-end.

引用

页码：993 / 1005

页数：13

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