SYNTHESIS OF 2',3'-DIDEOXYCYCLO-2'-PENTENYL-3'-C-HYDROXYMETHYL CARBOCYCLIC NUCLEOSIDE ANALOGS AS POTENTIAL ANTIVIRAL AGENTS

被引：35

作者：

WACHTMEISTER, J

CLASSON, B

SAMUELSSON, B

KVARNSTROM, I

机构：

[1] UNIV STOCKHOLM,DEPT ORGAN CHEM,ARRHENIUS LAB,S-10691 STOCKHOLM,SWEDEN

[2] AB HASSLE,MED CHEM,S-43183 MOLNDAL,SWEDEN

[3] LINKOPING UNIV,DEPT CHEM,S-58183 LINKOPING,SWEDEN

来源：

TETRAHEDRON | 1995年 / 51卷 / 07期

关键词：

D O I：

10.1016/0040-4020(94)01067-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of optically pure unsaturated carbocyclic nucleoside analogues is described. (3,4S)-Bis(t-butyldiphenylsilyloxymethyl)-2-cyclopenten-1R and 1S-ol were coupled with 6-chloropurine and 2-amino-6-chloropurine respectively, using a modified Mitsunobu reaction. The products were reacted further using standard procedures to give compounds 12, 14, 16 and 18 which were tested for anti-HIV activity.

引用

页码：2029 / 2038

页数：10

共 35 条

[1] SYNTHESIS OF CARBOCYCLIC NUCLEOSIDES [J].