MECHANISM OF THE REACTION CATALYZED BY DIHYDROFOLATE-REDUCTASE FROM ESCHERICHIA-COLI - PH AND DEUTERIUM-ISOTOPE EFFECTS WITH NADPH AS THE VARIABLE SUBSTRATE

被引:89
作者
MORRISON, JF
STONE, SR
机构
关键词
D O I
10.1021/bi00415a017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:5499 / 5506
页数:8
相关论文
共 29 条
[11]  
ELLIS KJ, 1982, METHOD ENZYMOL, V87, P405
[12]   CONSTRUCTION AND EVALUATION OF THE KINETIC SCHEME ASSOCIATED WITH DIHYDROFOLATE-REDUCTASE FROM ESCHERICHIA-COLI [J].
FIERKE, CA ;
JOHNSON, KA ;
BENKOVIC, SJ .
BIOCHEMISTRY, 1987, 26 (13) :4085-4092
[13]  
FILMAN DJ, 1982, J BIOL CHEM, V257, P13663
[14]   FUNCTIONAL-ROLE OF ASPARTIC ACID-27 IN DIHYDROFOLATE-REDUCTASE REVEALED BY MUTAGENESIS [J].
HOWELL, EE ;
VILLAFRANCA, JE ;
WARREN, MS ;
OATLEY, SJ ;
KRAUT, J .
SCIENCE, 1986, 231 (4742) :1123-1128
[15]  
HUENNEKENS F. M., 1964, P355
[16]   THE TRYPSIN-CATALYZED HYDROLYSIS OF BENZOYL-L-ARGININE ETHYL ESTER .1. THE KINETICS IN DIOXANE-WATER MIXTURES [J].
INAGAMI, T ;
STURTEVANT, JM .
BIOCHIMICA ET BIOPHYSICA ACTA, 1960, 38 (01) :64-79
[17]  
LUND H, 1975, CHEM BIOL PTERIDINES, V5, P645
[18]  
MATTHEWS DA, 1985, J BIOL CHEM, V260, P381
[19]  
MORRISON J F, 1986, P827
[20]   DIHYDROFOLATE REDUCTASE FROM L121OR MURINE LYMPHOMA . FLUOROMETRIC MEASUREMENTS OF INTERACTION OF ENZYME WITH COENZYMES SUBSTRATES AND INHIBITORS [J].
PERKINS, JP ;
BERTINO, JR .
BIOCHEMISTRY, 1966, 5 (03) :1005-&