ENZYME-CATALYZED DESYMMETRIZATION OF MESO-SKIPPED POLYOLS TO USEFUL CHIRAL BUILDING-BLOCKS

被引：29

作者：

BONINI, C ^{[1
]}

RACIOPPI, R ^{[1
]}

VIGGIANI, L ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO CHIM,CARDIAC SURG,CTR STUDIO CHIM SOSTANZE NAT,I-00185 ROME,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(00)80117-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The biocatalytic desymmetrization, in presence of different enzymes, of two models of polyfunctionalized diols in a meso form was studied PFL was found to be the most selective enzyme with excellent results in chemical and optical yield with some of the tested substrates. The obtained chiral building block was utilized for some useful synthetic transformations toward the synthesis of natural products.

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页码：793 / 805

页数：13

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