SYNTHESIS OF FUNCTIONALIZED FURO[2,3-B]PYRIDINES VIA THE PD-CATALYZED COUPLING OF ACETYLENES TO IODOPYRIDONES - PREPARATION OF A KEY INTERMEDIATE TO A NEW HIV PROTEASE INHIBITOR L-754,394

被引：55

作者：

HOUPIS, IN

CHOI, WB

REIDER, PJ

MOLINA, A

CHURCHILL, H

LYNCH, J

VOLANTE, RP

机构：

[1] Process Research, Merck Research Laboratories, Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(00)78541-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1 was accomplished in 55% overall yield via the Pd-catalyzed coupling of 3 and 4 followed by Cu-catalyzed cyclization of the resulting intermediate 2.

引用

页码：9355 / 9358

页数：4

共 18 条

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