PHARMACEUTICAL HETEROGENEOUS SYSTEMS .4. A KINETIC APPROACH TO STABILITY SCREENING OF SOLID DOSAGE FORMS CONTAINING ASPIRIN

被引：25

作者：

MAULDING, HV

ZOGLIO, MA

PIGOIS, FE

WAGNER, M

机构：

[1] Pharmacy Research and Development Department of Sandoz Pharmaceuticals, Hanocer, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 11期

关键词：

Aspirin dosage forms—stability screening; Colorimetric analysis—spectrophotometer; Heterogeneous systems—pharmaceutical; Stability; aspirin dosage forms—kinetic ranking; UV spectrophotometry—analysis;

D O I：

10.1002/jps.2600581112

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of common tablet excipients and physiologically active materials on the hydrolysis of aspirin in aqueous suspension has been studied. The relationship of hydrolytic rate to solvent concentration in these systems has been determined. The results obtained have been utilized in the stability ranking for various tablet mixes. The kinetic ranking is compared to the relative stability of tablets and powders. An attempt is made to correlate extrapolated kinetic data with stability results for the tablets. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

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页码：1359 / &

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