A VERSATILE ENTRY INTO THE SYNTHESIS OF ALPHA-(MONOFLUOROMETHYL) AMINO-ACIDS - PREPARATION OF ALPHA-(MONOFLUOROMETHYL) SERINE AND (E)-DEHYDRO-ALPHA-(MONOFLUOROMETHYL) ORNITHINE

被引：8

作者：

VANHIJFTE, L

HEYDT, V

KOLB, M

机构：

[1] Marion Merrell Dow Research Institute Strasbourg Research Center, 67009 Strasbourg Cedex

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(00)74090-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new entry to the synthesis of alpha-(monofluoromethyl) amino acids is described. The synthesis is based on a Strecker reaction on an alpha-(monofluoromethyl) ketone. As an example, alpha-(monofluoromethyl) serine was synthesized and used as starting material for a new synthesis of (E)-dehydro-alpha-(monofluromethyl ornithine.

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页码：4793 / 4796

页数：4

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