BIOLOGICAL-ACTIVITIES OF CYANOBACTERIA - EVALUATION OF EXTRACTS AND PURE COMPOUNDS

被引：107

作者：

FALCH, BS

KONIG, GM

WRIGHT, AD

STICHER, O

ANGERHOFER, CK

PEZZUTO, JM

BACHMANN, H

机构：

[1] ETH ZURICH, DEPT PHARM, CH-8057 ZURICH, SWITZERLAND

[2] UNIV ILLINOIS, COLL PHARM, DEPT MED CHEM & PHARMACOGNOSY, PROGRAM COLLABORAT RES PHARMACEUT SCI, CHICAGO, IL 60612 USA

[3] SWISS FED INST WATER RESOURCES & WATER POLLUT CON, CH-8600 DUBENDORF, SWITZERLAND

来源：

PLANTA MEDICA | 1995年 / 61卷 / 04期

关键词：

CYANOBACTERIA; BRINE SHRIMP LETHALITY; CYTOTOXIC; ANTIMICROBIAL; FISCHERELLA AMBIGUA; AMBIGOL A; AMBIGOL B; TJIPANAZOLE D;

D O I：

10.1055/s-2006-958092

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A total of 80 lipophilic and hydrophilic extracts obtained from 20 samples of cultured freshwater and terrestrial cyanobacteria were investigated for their biological activities. Of all the extracts, 26 % exhibited a significant lethal effect against brine shrimp. Out of 54 extracts tested for antimicrobial activity, 78 % showed antibacterial and 45 % antifungal activities. Of 30 extracts tested for cytotoxicity against KB cells, none was found to be active. Bioassay-guided fractionation of the lipophilic extracts of Fischerella ambigua led to the isolation of three compounds; ambigols A (1) and B (2), and tjipanazole D (3). Compounds 1 and 2 exhibited antibacterial, antifungal, cytotoxic, molluscicidal, anti-inflammatory, and antiviral activities. Tjipanazole D (3) showed moderate antibacterial properties.

引用

收藏

页码：321 / 328

页数：8

相关论文

共 40 条

[1] ANTIGEN-INDUCED PROLIFERATION ASSAY FOR MOUSE T-LYMPHOCYTES - RESPONSE TO A MONO-VALENT ANTIGEN [J].

ALKAN, SS .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1978, 8 (02) :112-118

[2] ACUTIPHYCIN AND 20,21-DIDEHYDROACUTIPHYCIN, NEW ANTINEOPLASTIC AGENTS FROM THE CYANOPHYTE OSCILLATORIA-ACUTISSIMA [J].

BARCHI, JJ ;

MOORE, RE ;

PATTERSON, GML .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (26) :8193-8197

[3] INTERLEUKIN-1 ACTS ON CULTURED HUMAN VASCULAR ENDOTHELIUM TO INCREASE THE ADHESION OF POLYMORPHONUCLEAR LEUKOCYTES, MONOCYTES, AND RELATED LEUKOCYTE CELL-LINES [J].

BEVILACQUA, MP ;

POBER, JS ;

WHEELER, ME ;

COTRAN, RS ;

GIMBRONE, MA .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (05) :2003-2011

[4] TJIPANAZOLES, NEW ANTIFUNGAL AGENTS FROM THE BLUE-GREEN-ALGA TOLYPOTHRIX-TJIPANASENSIS [J].

BONJOUKLIAN, R ;

SMITKA, TA ;

DOOLIN, LE ;

MOLLOY, RM ;

DEBONO, M ;

SHAFFER, SA ;

MOORE, RE ;

STEWART, JB ;

PATTERSON, GML .

TETRAHEDRON, 1991, 47 (37) :7739-7750

[5] TOLYTOXIN AND NEW SCYTOPHYCINS FROM 3 SPECIES OF SCYTONEMA [J].

CARMELI, S ;

MOORE, RE ;

PATTERSON, GML .

JOURNAL OF NATURAL PRODUCTS, 1990, 53 (06) :1533-1542

[6] CYANOBACTERIA SECONDARY METABOLITES - THE CYANOTOXINS [J].

CARMICHAEL, WW .

JOURNAL OF APPLIED BACTERIOLOGY, 1992, 72 (06) :445-459

[7] POLYBROMINATED DIPHENYL ETHERS FROM DYSIDEA-HERBACEA, DYSIDEA-CHLOREA AND PHYLLOSPONGIA-FOLIASCENS [J].

CARTE, B ;

FAULKNER, DJ .

TETRAHEDRON, 1981, 37 (13) :2335-2339

[8] QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].

DESJARDINS, RE ;

CANFIELD, CJ ;

HAYNES, JD ;

CHULAY, JD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (06) :710-718

[9] AMBIGOL A AND B - NEW BIOLOGICALLY-ACTIVE POLYCHLORINATED AROMATIC-COMPOUNDS FROM THE TERRESTRIAL BLUE-GREEN-ALGA FISCHERELLA-AMBIGUA [J].

FALCH, BS ;

KONIG, GM ;

WRIGHT, AD ;

STICHER, O ;

RUEGGER, H ;

BERNARDINELLI, G .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (24) :6570-6575

[10] STRUCTURE OF CURACIN-A, A NOVEL ANTIMITOTIC, ANTIPROLIFERATIVE, AND BRINE SHRIMP TOXIC NATURAL PRODUCT FROM THE MARINE CYANOBACTERIUM LYNGBYA-MAJUSCULA [J].

GERWICK, WH ;

PROTEAU, PJ ;

NAGLE, DG ;

HAMEL, E ;

BLOKHIN, A ;

SLATE, DL .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (06) :1243-1245

← 1 2 3 4 →