NOVEL IMIDAZOLONE COMPOUND FORMED BY THE ADVANCED MAILLARD REACTION OF 3-DEOXYGLUCOSONE AND ARGININE RESIDUES IN PROTEINS

被引：72

作者：

KONISHI, Y

HAYASE, F

KATO, H

机构：

[1] UNIV TOKYO, DEPT AGR CHEM, BUNKYO KU, TOKYO 113, JAPAN

[2] MEIJI UNIV, DEPT AGR CHEM, TAMA KU, KAWASAKI, KANAGAWA 214, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1994年 / 58卷 / 11期

关键词：

D O I：

10.1271/bbb.58.1953

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Similar unknown peaks were detected on an amino acid chromatogram of the acid hydrolysates in 3-deoxyglucosone (3DG)-lysozyme as well as glucose-lysozyme reaction systems. Unknown peaks were also detected in the acid hydrolysates of 3DG and N-alpha-benzoylarginine amide (BzArgNH(2)) reaction system. By this system, several products were purified by reversed-phase HPLC and subjected to a FAB-MS analysis. The mass spectral data showed that the major products were formed from one molecule of BzArgNH, and from one or two molecules of 3-DG. The major product was identified as 2-(4-benzoylamino-5-pentamide)-amino-5-(2,3,4-trihydroxybutyl)-4-imidazolone.

引用

页码：1953 / 1955

页数：3

共 21 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR
BAX, A
SUMMERS, MF
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) : 2093 - 2094
[2] HYPOTHESIS - GLUCOSE AS A MEDIATOR OF AGING
CERAMI, A
[J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1985, 33 (09) : 626 - 634
[3] CHO DB, 1986, AGR BIOL CHEM TOKYO, V13, P439
[4] POLYMERIZATION OF ACETYLATED LYSOZYME AND IMPAIRMENT OF THEIR AMINO-ACID-RESIDUES DUE TO ALPHA-DICARBONYL AND ALPHA-HYDROXYCARBONYL COMPOUNDS
CHO, RK
OKITANI, A
KATO, H
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1986, 50 (06): : 1373 - 1380
[5] HAYASE F, 1989, J BIOL CHEM, V264, P3758
[6] METABOLISM OF 3-DEOXYGLUCOSONE, AN INTERMEDIATE COMPOUND IN THE MAILLARD REACTION, ADMINISTERED ORALLY OR INTRAVENOUSLY TO RATS
KATO, H
VANCHUYEN, N
SHINODA, T
SEKIYA, F
HAYASE, F
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1035 (01) : 71 - 76
[7] 3-DEOXYGLUCOSONE CROSS-LINKS PROTEINS UNDER PHYSIOLOGICAL CONDITIONS
KATO, H
SHIN, DB
HAYASE, F
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1987, 51 (07): : 2009 - 2011
[8] RESPONSIBILITY OF 3-DEOXYGLUCOSONE FOR THE GLUCOSE-INDUCED POLYMERIZATION OF PROTEINS
KATO, H
CHO, RK
OKITANI, A
HAYASE, F
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1987, 51 (03): : 683 - 689
[9] KISHI Y, 1966, TETRAHEDRON LETT, V29, P3427
[10] KISHI YOSHITO, 1966, TETRAHEDRON LETT, V29, P3445

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