TOWARDS A TANDEM-RADICAL MACROCYCLIZATION-TRANSANNULAR CYCLIZATION APPROACH TO STEROIDS - TRANSANNULAR CYCLIZATIONS OF A MACROCYCLIC CORE

被引：20

作者：

JAHN, U ^{[1
]}

CURRAN, DP ^{[1
]}

机构：

[1] UNIV PITTSBURGH,DEPT CHEM,PITTSBURGH,PA 15260

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 49期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)01918-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The triple transannular radical cyclization of 1-cyano-5-methyl-1-phenylseleno-8-hydroxy-4,9,13-cycloheptadecatriene (1a) provided a product 2 possessing the steroid ring skeleton of unassigned configuration in 4% isolated yield. A high yielding transannular cyclization of the related diene lacking the Delta(4,5)-double bond identifies the second cyclization as the Achilles heel of the triene cyclization.

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收藏

页码：8921 / 8924

页数：4

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