ANTI-SEDATIVE AND ANTI-CATALEPTIC PROPERTIES OF NCS-382, A GAMMA-HYDROXYBUTYRATE RECEPTOR ANTAGONIST

被引：56

作者：

SCHMIDT, C ^{[1
]}

GOBAILLE, S ^{[1
]}

HECHLER, V ^{[1
]}

SCHMITT, M ^{[1
]}

BOURGUIGNON, JJ ^{[1
]}

MAITRE, M ^{[1
]}

机构：

[1] CNRS,CTR NEUROCHIM,5 RUE BLAISE PASCAL,F-67084 STRASBOURG,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 203卷 / 03期

关键词：

GAMMA-HYDROXYBUTYRATE RECEPTORS; GAMMA-HYDROXYBUTYRATE RECEPTOR ANTAGONISTS; SEDATIVE ANESTHETIC EFFECTS; BRAIN (RAT); NCS-382; CATALEPSY; NEUROLEPTICS;

D O I：

10.1016/0014-2999(91)90896-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

NCS-382 possesses antagonistic properties at gamma-hydroxybutyrate receptor sites. Its effect on the sedative/cataleptic behaviour observed in rats after gamma-hydroxybutyrate administration was investigated. NCS-382 diminished, in a dose-dependent manner, the sedative and/or cataleptic effects of gamma-hydroxybutyrate, as revealed by a variety of sensorimotor tests. These results indicate that the well-known sedative/anaesthetic effects induced by gamma-hydroxybutyrate administration are provoked via stimulation of a specific class(es) of gamma-hydroxybutyrate receptors which exist in the rat brain and which could mediate a local stimulation of opiate synthesis and release.

引用

页码：393 / 397

页数：5

共 27 条

[1] EFFECT OF CHRONIC TYPICAL AND ATYPICAL NEUROLEPTIC TREATMENT ON PROENKEPHALIN MESSENGER-RNA LEVELS IN THE STRIATUM AND NUCLEUS-ACCUMBENS OF THE RAT [J].

ANGULO, JA ;

CADET, JL ;

WOOLLEY, CS ;

SUBER, F ;

MCEWEN, BS .

JOURNAL OF NEUROCHEMISTRY, 1990, 54 (06) :1889-1894

[2] HIGH-AFFINITY BINDING-SITE FOR GAMMA-HYDROXYBUTYRIC ACID IN RAT-BRAIN [J].

BENAVIDES, J ;

RUMIGNY, JF ;

BOURGUIGNON, JJ ;

CASH, C ;

WERMUTH, CG ;

MANDEL, P ;

VINCENDON, G ;

MAITRE, M .

LIFE SCIENCES, 1982, 30 (11) :953-961

[3]

COSTENTIN J, 1987, NEUROLEPTIQUES, P142

[4] LOCAL ENKEPHALINS TONICALLY MODULATE DOPAMINE RELEASE IN THE STRIATUM - A MICRODIALYSIS STUDY [J].

DOURMAP, N ;

MICHAELTITUS, A ;

COSTENTIN, J .

BRAIN RESEARCH, 1990, 524 (01) :153-155

[5] DOPAMINE-RICH GRAFTS AMELIORATE WHOLE-BODY MOTOR ASYMMETRY AND SENSORY NEGLECT BUT NOT INDEPENDENT LIMB USE IN RATS WITH 6-HYDROXYDOPAMINE LESIONS [J].

DUNNETT, SB ;

WHISHAW, IQ ;

ROGERS, DC ;

JONES, GH .

BRAIN RESEARCH, 1987, 415 (01) :63-78

[6] ANTAGONISM OF GAMMA-HYDROXYBUTYRATE-INDUCED HYPER-SYNCHRONIZATION IN ECOG OF RAT BY ANTI-PETIT MAL DRUGS [J].

GODSCHALK, M ;

DZOLJIC, MR ;

BONTA, IL .

NEUROSCIENCE LETTERS, 1976, 3 (03) :145-150

[7] SLOW-WAVE SLEEP AND A STATE RESEMBLING ABSENCE EPILEPSY INDUCED IN RAT BY GAMMA-HYDROXYBUTYRATE [J].

GODSCHALK, M ;

DZOLJIC, MR ;

BONTA, IL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1977, 44 (02) :105-111

[8] REGIONAL DISTRIBUTION OF HIGH-AFFINITY GAMMA-[H-3] HYDROXYBUTYRATE BINDING-SITES AS DETERMINED BY QUANTITATIVE AUTORADIOGRAPHY [J].

HECHLER, V ;

WEISSMANN, D ;

MACH, E ;

PUJOL, JF ;

MAITRE, M .

JOURNAL OF NEUROCHEMISTRY, 1987, 49 (04) :1025-1032

[9] EXTRACELLULAR EVENTS INDUCED BY GAMMA-HYDROXYBUTYRATE IN STRIATUM - A MICRODIALYSIS STUDY [J].

HECHLER, V ;

GOBAILLE, S ;

BOURGUIGNON, JJ ;

MAITRE, M .

JOURNAL OF NEUROCHEMISTRY, 1991, 56 (03) :938-944

[10]

Hoes M J, 1980, Encephale, V6, P93

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