THE MELANOMA ANTIGEN GENE (MAGE) FAMILY IS CLUSTERED IN THE CHROMOSOMAL BAND XQ28

被引：116

作者：

ROGNER, UC ^{[1
]}

WILKE, K ^{[1
]}

STECK, E ^{[1
]}

KORN, B ^{[1
]}

POUSTKA, A ^{[1
]}

机构：

[1] DEUTSCH KREBSFORSCHUNGSZENTRUM,MOLEK GENOMANAL ABT,D-69120 HEIDELBERG,GERMANY

来源：

GENOMICS | 1995年 / 29卷 / 03期

关键词：

D O I：

10.1006/geno.1995.9945

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The melanoma antigen gene (MAGE) family comprises 12 known genes, of which 6 are expressed in tumors. In the course of a systematic analysis of transcripts in Xq28, we have identified cDNAs related to different MAGE genes. Analysis of cell hybrids, ordered YACs, and cosmids showed that all MAGE genes are located in Xq28 and are clustered in three main intervals within 3.5 Mb. The six genes expressed in tumors are contained in the two intervals closest to the telomere and are highly homologous to each other. Analysis of different species suggests that human MAGE sequences are conserved in primates, but less well conserved in other vertebrate species. (C) 1995 Academic Press, Inc.

引用

页码：725 / 731

页数：7

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