PIPERIDINE-ETHER BASED HNK(1) ANTAGONISTS .2. INVESTIGATION OF THE EFFECT OF N-SUBSTITUTION

被引：24

作者：

HARRISON, T

OWENS, AP

WILLIAMS, BJ

SWAIN, CJ

BAKER, R

HUTSON, PH

SADOWSKI, S

CASCIERI, MA

机构：

[1] MERCK SHARP & DOHME LTD,RES LABS,NEUROSCI RES CTR,DEPT BIOCHEM,HARLOW CM20 2QR,ESSEX,ENGLAND

[2] MERCK & CO INC,MERCK SHARP & DOHME RES LABS,DEPT MOLEC PHARMACOL & BIOCHEM,RAHWAY,NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 03期

关键词：

D O I：

10.1016/0960-894X(95)00009-I

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of nitrogen substitution on the binding affinity of the piperidine-ether substance P antagonist L-733,060 for the hNK(1) receptor and L-type Ca2+ channel is discussed.

引用

页码：209 / 212

页数：4

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