Oligonucleotides containing acyclic nucleoside analogues with carbamate internucleoside linkages

被引：12

作者：

Habus, I ^{[1
]}

Agrawal, S ^{[1
]}

机构：

[1] HYBRIDON INC,WORCESTER,MA 01605

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 9-10期

关键词：

D O I：

10.1080/15257779508010708

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis of 2'-deoxy-2',3'-secothymidine t and its dimer t*t, where the two 2'-deoxy-2',3'-secothymidine t units are connected via a carbamate, *=3'-NH-CO-O-5', internucleoside linkage has been achieved. These building blocks were protected in the 5'-position, converted into their phosphoramidites, or attached onto CPG, and then used for ''chimeric oligonucleotide'' synthesis.

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页码：1853 / 1859

页数：7

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