SYNTHESIS AND ANTIVIRAL EVALUATION OF 2',3'-SECOTHYMIDINE ANALOGS OF DDT AND AZT

被引：12

作者：

MAGGIO, AF

BOYER, V

AUBERTIN, AM

OBERT, G

KIRN, A

IMBACH, JL

机构：

[1] UNIV SCI & TECH LANGUEDOC 2, CHIM BIOORGAN LAB,CNRS,UMR 112,SYNTHELAB, PL EUGENE BATAILLON, F-34095 MONTPELLIER 5, FRANCE

[2] UNIV STRASBOURG 1, FAC MED, VIROL LAB, INSERM, U74, F-67070 STRASBOURG, FRANCE

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1991年 / 10卷 / 07期

关键词：

D O I：

10.1080/07328319108046673

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2',3'-Secothymidine derivatives related to AZT and ddT have been synthesized and evaluated for their activity against HIV-1 and various DNA and RNA viruses. These acyclic nucleosides exhibited no antiviral activities.

引用

页码：1431 / 1449

页数：19

共 43 条

[1] SYNTHESIS OF DEOXYHALOGENO SUGARS - REACTION OF HALIDE-IONS WITH 1,2,3,4-TETRA-O-ACETYL-6-O-[(TRIFLUOROMETHYL)SULFONYL]-BETA-D-GLUCOPYRANOSE [J].

AMBROSE, MG ;

BINKLEY, RW .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (05) :674-677

[2] ACTIVATION BY THYMIDINE KINASE AND POTENT ANTIHERPETIC ACTIVITY OF 2'-NOR-2'-DEOXYGUANOSINE (2'NDG) [J].

ASHTON, WT ;

KARKAS, JD ;

FIELD, AK ;

TOLMAN, RL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 108 (04) :1716-1721

[3] BOTH 2',3'-DIDEOXYTHYMIDINE AND ITS 2',3'-UNSATURATED DERIVATIVE (2',3'-DI-DEOXYTHYMIDINENE) ARE POTENT AND SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-REPLICATION INVITRO [J].

BABA, M ;

PAUWELS, R ;

HERDEWIJN, P ;

DECLERCQ, E ;

DESMYTER, J ;

VANDEPUTTE, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (01) :128-134

[4] THE 2',3'-DIDEOXYRIBOSIDE OF 2,6-DIAMINOPURINE SELECTIVELY INHIBITS HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) REPLICATION INVITRO [J].

BALZARINI, J ;

PAUWELS, R ;

BABA, M ;

ROBINS, MJ ;

ZOU, R ;

HERDEWIJN, P ;

DECLERCQ, E .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 145 (01) :269-276

[5] ANTI-RETROVIRUS ACTIVITY OF 3'-FLUORO-SUBSTITUTED AND 3'-AZIDO-SUBSTITUTED PYRIMIDINE 2',3'-DIDEOXYNUCLEOSIDE ANALOGS [J].

BALZARINI, J ;

BABA, M ;

PAUWELS, R ;

HERDEWIJN, P ;

DECLERCO, E .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (14) :2847-2856

[6] NEW METHOD FOR DEOXYGENATION OF SECONDARY ALCOHOLS [J].

BARTON, DHR ;

MCCOMBIE, SW .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1975, (16) :1574-1585

[7] ONE POT SOLID-PHASE CLEAVAGE OF ALPHA-DIOLS TO PRIMARY ALCOHOLS - AN ATTRACTIVE ROUTE TO TRIHYDROXY-NUCLEOSIDES, ANTIVIRAL PRECURSORS [J].

BESSODES, M ;

ANTONAKIS, K .

TETRAHEDRON LETTERS, 1985, 26 (10) :1305-1306

[8] SYNTHESIS AND REACTIONS OF CARBOHYDRATE TRIFLUOROMETHANESULFONATES (CARBOHYDRATE TRIFLATES) [J].

BINKLEY, RW ;

AMBROSE, MG .

JOURNAL OF CARBOHYDRATE CHEMISTRY, 1984, 3 (01) :1-49

[9] INITIAL STUDIES ON THE CELLULAR PHARMACOLOGY OF 2',3'-DIDEOXYADENOSINE, AN INHIBITOR OF HTLV-III INFECTIVITY [J].

COONEY, DA ;

AHLUWALIA, G ;

MITSUYA, H ;

FRIDLAND, A ;

JOHNSON, M ;

HAO, Z ;

DALAL, M ;

BALZARINI, J ;

BRODER, S ;

JOHNS, DG .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (11) :1765-1768

[10] SELECTIVITY OF ACTION OF AN ANTI-HERPETIC AGENT, 9-(2-HYDROXYETHOXYMETHYL)GUANINE [J].

ELION, GB ;

FURMAN, PA ;

FYFE, JA ;

DEMIRANDA, P ;

BEAUCHAMP, L ;

SCHAEFFER, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5716-5720

← 1 2 3 4 5 →