DNA METHYLATION AND CELLULAR AGING

被引：41

作者：

CATANIA, J

FAIRWEATHER, DS

机构：

[1] UNIV OXFORD, NUFFIELD DEPT CLIN MED, OXFORD, ENGLAND

[2] UNIV MANCHESTER, DEPT GERIATR MED, MANCHESTER M13 9PL, LANCS, ENGLAND

来源：

MUTATION RESEARCH | 1991年 / 256卷 / 2-6期

关键词：

5-METHYLCYTOSINE; DNA METHYLATION; EPIGENETIC; GENE REGULATION; AGING;

D O I：

10.1016/0921-8734(91)90019-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Methylated cytosine (m5C) in DNA appears to be an important modulator of the expression of some genes. There are several lines of evidence that gradual loss of m5C is relevant to in vitro cellular ageing: m5C loss occurs during cell culture; m5C loss is detectable at an early stage of culture; m5C loss appears to be related to cell division not just duration in culture; the rate of m5C loss appears to be related to in vitro lifespan of the cell strain in question; and the total loss of m5C during an in vitro lifespan is significant by comparison with induced-changes in m5C levels which effect cell growth, or cause cell-death in culture. Progressive loss of m5C in dividing cells may thus produce the multi-step cell division "clock" which underlies the Hayflick phenomenon.

引用

页码：283 / 293

页数：11

共 84 条

[11] CATANIA J, 1988, THESIS U MANCHESTER
[12] CATANIA J, 1990, AGE AGEING S2, V19, pP26
[13] POSITION EFFECT VARIEGATION IN MOUSE
CATTANACH, BM
[J]. GENETICS RESEARCH, 1974, 23 (03) : 291 - +
[14] DNA METHYLATION AND GENE ACTIVITY
CEDAR, H
[J]. CELL, 1988, 53 (01) : 3 - 4
[15] DIRECT DETECTION OF METHYLATED CYTOSINE IN DNA BY USE OF THE RESTRICTION ENZYME MSPI
CEDAR, H
SOLAGE, A
GLASER, G
RAZIN, A
[J]. NUCLEIC ACIDS RESEARCH, 1979, 6 (06) : 2125 - 2132
[16] HYPOMETHYLATION OF DNA DURING DIFFERENTIATION OF FRIEND-ERYTHROLEUKEMIA CELLS
CHRISTMAN, JK
WEICH, N
SCHOENBRUN, B
SCHNEIDERMAN, N
ACS, G
[J]. JOURNAL OF CELL BIOLOGY, 1980, 86 (02) : 366 - 370
[17] EXPRESSION OF TRANSFERRED THYMIDINE KINASE GENES IS CONTROLLED BY METHYLATION
CHRISTY, B
SCANGOS, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (20): : 6299 - 6303
[18] CUTLER RG, 1982, TESTING THEORIES AGE
[19] DNA METHYLATION OF MAIZE TRANSPOSABLE ELEMENTS IS CORRELATED WITH ACTIVITY
DENNIS, ES
BRETTELL, RIS
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1990, 326 (1235) : 217 - 229
[20] METHYLATION OF HERPESVIRUS-SAIMIRI DNA IN LYMPHOID TUMOR-CELL LINES
DESROSIERS, RC
MULDER, C
FLECKENSTEIN, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (08) : 3839 - 3843

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