DNA METHYLATION AND CELLULAR AGING

被引：41

作者：

CATANIA, J

FAIRWEATHER, DS

机构：

[1] UNIV OXFORD, NUFFIELD DEPT CLIN MED, OXFORD, ENGLAND

[2] UNIV MANCHESTER, DEPT GERIATR MED, MANCHESTER M13 9PL, LANCS, ENGLAND

来源：

MUTATION RESEARCH | 1991年 / 256卷 / 2-6期

关键词：

5-METHYLCYTOSINE; DNA METHYLATION; EPIGENETIC; GENE REGULATION; AGING;

D O I：

10.1016/0921-8734(91)90019-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Methylated cytosine (m5C) in DNA appears to be an important modulator of the expression of some genes. There are several lines of evidence that gradual loss of m5C is relevant to in vitro cellular ageing: m5C loss occurs during cell culture; m5C loss is detectable at an early stage of culture; m5C loss appears to be related to cell division not just duration in culture; the rate of m5C loss appears to be related to in vitro lifespan of the cell strain in question; and the total loss of m5C during an in vitro lifespan is significant by comparison with induced-changes in m5C levels which effect cell growth, or cause cell-death in culture. Progressive loss of m5C in dividing cells may thus produce the multi-step cell division "clock" which underlies the Hayflick phenomenon.

引用

页码：283 / 293

页数：11