INHIBITION OF HUMAN BRAIN-TUMOR CELL-GROWTH BY A RECEPTOR-OPERATED CA2+ CHANNEL BLOCKER

被引：25

作者：

LEE, YS ^{[1
]}

SAYEED, MM ^{[1
]}

WURSTER, RD ^{[1
]}

机构：

[1] LOYOLA UNIV,MED CTR,DEPT PHYSIOL,2160 S 1ST AVE,MAYWOOD,IL 60153

来源：

CANCER LETTERS | 1993年 / 72卷 / 1-2期

关键词：

SK-AND-F; 96365; HUMAN BRAIN TUMOR; CA2+ MOBILIZATION;

D O I：

10.1016/0304-3835(93)90014-Z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

SK&F 96365, a reported receptor-operated Ca2+ channel blocker, inhibited the growth of U-373 MG human astrocytoma and SK-N-MC human neuroblastoma cell lines in a dose-dependent manner. Carbachol and serum which act as growth factors for these cells induced a rapid, transient increase of intracellular Ca2+ concentration without a sustained increase. SK&F 96365 also exerted a significant inhibition of carbachol or serum-induced intracellular Ca2+ mobilization. These results suggest that SK&F 96365 is a potent inhibitor of brain tumor cell growth and that its effect may be mediated by the inhibition of agonist-induced intracellular Ca2+ mobilization.

引用

页码：77 / 81

页数：5