ISOLATION AND CHARACTERIZATION OF A PRESUMED BIOSYNTHETIC PRECURSOR OF CAMPTOTHECIN FROM EXTRACTS OF CAMPTOTHECA-ACUMINATA

被引：38

作者：

CARTE, BK

DEBROSSE, C

EGGLESTON, D

HEMLING, M

MENTZER, M

POEHLAND, B

TROUPE, N

WESTLEY, JW

HECHT, SM

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT BIOMOLEC DISCOVERY,POB 1539,KING OF PRUSSIA,PA 19406

[2] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT ANALYT CHEM,KING OF PRUSSIA,PA 19406

[3] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT PHYS & STRUCT CHEM,KING OF PRUSSIA,PA 19406

[4] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

[5] UNIV VIRGINIA,DEPT BIOL,CHARLOTTESVILLE,VA 22901

来源：

TETRAHEDRON | 1990年 / 46卷 / 08期

关键词：

D O I：

10.1016/S0040-4020(01)88369-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A biosynthetic precursor 4 of the antitumor alkaloid camptothecin (1) has been isolated from alkaloid enriched extracts of Camptotheca acuminata. The structure of 4, which was determined both in the solid state by x-ray diffraction and in solution by NMR analysis, provides strong evidence in support of the proposed biosynthetic scheme for camptothecin (1). © 1990.

引用

页码：2747 / 2760

页数：14

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