SYNTHESIS OF CYCLOPENTANE SPIROHYDANTOINS BY ALDOL CYCLIZATIONS - AN APPROACH TO HIGHLY SUBSTITUTED ALPHA-CYCLOPENTANE AMINO-ACIDS

被引：12

作者：

FAIRBANKS, AJ

ELLIOTT, RP

SMITH, C

HUI, A

WAY, G

STORER, R

TAYLOR, H

WATKIN, DJ

WINCHESTER, BG

FLEET, GWJ

机构：

[1] OXFORD CTR MOLEC SCI,DYSON PERKINS LAB,OXFORD OX1 3QY,OXON,ENGLAND

[2] UNIV OXFORD,CHEM CRYSTALLOG LAB,OXFORD OX1 3PD,OXON,ENGLAND

[3] UNIV LONDON,INST CHILD HLTH,LONDON WC1N 1EH,ENGLAND

[4] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(00)61521-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient but reversible aldol condensations of 2-azido-5-formyl-1,5-lactones provide short routes to precursors for alpha-cyclopentane amino acids, some aminopseudosugars and spirohydantoins of cyclopentanes with control of the stereochemistry at all 5 carbons bearing functional groups. The effects of some of the compounds on human liver glycosidases are described.

引用

页码：7953 / 7956

页数：4

共 8 条

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[3] THE SYNTHESIS OF PSEUDO-SUGARS RELATED TO ALLOSAMIZOLINE
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[5] SYNTHESIS OF 1-EPIHYDANTOCIDIN FROM D-RIBOSE
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[J]. TETRAHEDRON LETTERS, 1993, 34 (20) : 3327 - 3330
[6] FLEET GWJ, 1990, TETRAHEDRON, V46, P19
[7] SKEAD BM, 1993, TETRAHEDRON LETT, V34, P615
[8] TROST BM, 1993, J AM CHEM SOC, V115, P4458

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