INCREASED AMPHETAMINE POTENCY FOLLOWING CHRONIC NALTREXONE ADMINISTRATION IN RATS

被引：11

作者：

AMIR, S

BLAIR, R

AMIT, Z

机构：

[1] Center for Research on Drug Dependence Department of Psychology, Que. H3G 1M8

来源：

LIFE SCIENCES | 1979年 / 25卷 / 16期

关键词：

D O I：

10.1016/0024-3205(79)90418-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chronic administration of the long acting opiate antagonist naltrexone potentiated the amphetamine and apomorphine- -induced stimulation of locomotor activity in rats. Similar treatment also resulted in increased locomotor activity in saline injected rats. The results suggest that chronic opiate receptor blockade may lead to the development of supersensitivity in dopamine systems that mediate motor control. The results provide further support for the notion that endogenous opioids modulate the function of dopamine systems in the brain. © 1979.

引用

页码：1407 / 1412

页数：6

共 46 条

[1] EFFECT OF ACUTE AND CHRONIC NALOXONE ADMINISTRATION ON MOTOR ACTIVATION IN THE RAT
AMIR, S
SOLOMON, M
AMIT, Z
[J]. NEUROPHARMACOLOGY, 1979, 18 (02) : 171 - 173
[2] ENDOGENOUS OPIOID LIGANDS MAY MEDIATE STRESS-INDUCED CHANGES IN AFFECTIVE PROPERTIES OF PAIN RELATED BEHAVIOR IN RATS
AMIR, S
AMIT, Z
[J]. LIFE SCIENCES, 1978, 23 (11) : 1143 - 1152
[3] EVIDENCE FOR DOPAMINE RECEPTOR STIMULATION BY APOMORPHINE
ANDEN, NE
RUBENSON, A
FUXE, K
HOKFELT, T
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1967, 19 (09) : 627 - &
[4] BINDING OF LEUKENCEPHALIN-H-3 IN RAT STRIATUM - PARTIAL INHIBITION BY MORPHINE OR NALOXONE
AUDIGIER, Y
MALFROYCAMINE, B
SCHWARTZ, JC
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1977, 41 (02) : 247 - 248
[5] STIMULATION OF DOPAMINE SYNTHESIS IN CAUDATE-NUCLEUS BY INTRASTRIATAL ENKEPHALINS AND ANTAGONISM BY NALOXONE
BIGGIO, G
CASU, M
CORDA, MG
DIBELLO, C
GESSA, GL
[J]. SCIENCE, 1978, 200 (4341) : 552 - 554
[6] STIMULANT EFFECTS OF ENKEPHALIN MICRO-INJECTION INTO THE DOPAMINERGIC A10 AREA
BROEKKAMP, CLE
PHILLIPS, AG
COOLS, AR
[J]. NATURE, 1979, 278 (5704) : 560 - 562
[7] CARLSSON A, 1975, BASAL GANGLIA, P181
[8] BINDING OF OPIATES AND ENDOGENOUS OPIOID PEPTIDES TO NEUROLEPTIC RECEPTOR-SITES IN CORPUS STRIATUM
CZLONKOWSKI, A
HOLLT, V
HERZ, A
[J]. LIFE SCIENCES, 1978, 22 (11) : 953 - 962
[9] INTRAVENOUS NALOXONE ADMINISTRATION IN SCHIZOPHRENIA AND AFFECTIVE-ILLNESS
DAVIS, GC
BUNNEY, WE
DEFRAITES, EG
KLEINMAN, JE
VANKAMMEN, DP
POST, RM
WYATT, RJ
[J]. SCIENCE, 1977, 197 (4298) : 74 - 77
[10] NALOXONE ANTAGONIZES BEHAVIORAL-EFFECTS OF D-AMPHETAMINE IN MICE AND RATS
DETTMAR, PW
COWAN, A
WALTER, DS
[J]. NEUROPHARMACOLOGY, 1978, 17 (12) : 1041 - 1044

← 1 2 3 4 5 →